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Gamma Cyhalothrin’in Dreissena polymorpha’daki Toksik Etkisinin Bazı Biyobelirteçlerle Belirlenmesi

Yıl 2025, Cilt: 11 Sayı: 1, 20 - 32, 30.04.2025

Ayşe Nur Aydın , Osman Serdar , Tuba Parlak Ak

https://doi.org/10.17216/limnofish.1556682

Öz

Bu çalışmada, pestisitlerin hedef olmayan organizmalar olan tatlı su midyesi Dreissena polymorpha üzerindeki etkilerinin biyokimyasal tepkilerle belirlenmesi amaçlandı. Bu amaçla öncelikle Gamma Cyhalothrin (GCH) pestisitinin D. polymorpha üzerindeki akut toksisite değeri (LC50) standart statik yöntemle belirlenmiş ve probit analizi ile 13,64 mg/L hesaplanmıştır. Daha sonra 24 ve 96 saat boyunca ölümcül olmayan GCH konsantrasyonlarına maruz kalan D. polymorpha türünün süperoksit dismutaz (SOD), glutatyon peroksidaz (GPx), katalaz (CAT) aktiviteleri, malondialdehit (MDA) ve glutatyon (GSH) düzeyi tepkileri belirlendi. Biyokimyasal biyobelirteçlerin yanı sıra histopatolojik yanıtlar da değerlendirildi. Sonuç olarak, bu çalışma GCH pestisitlerinin oksidatif stresi tetikleme yeteneklerini ortaya koydu. Ayrıca MDA, GSH düzeyleri, SOD, CAT, GPx aktiviteleri ve histopatolojik yanıtlar da D. polymorpha'da etkili bir biyobelirteç olarak kullanılabilir.

Anahtar Kelimeler

Dreissena polymorpha gamma cyhalothrin biyobelirteç oksidatif stres histoloji

Kaynakça

  • Altıkat A, Turan T, Ekmekyapar Torun F, Bingül Z. 2009. Türkiye’de Pestisit Kullanımı ve Çevreye Olan Etkileri. Atatürk Üniv Ziraat Fak Derg. 40(2):87-92. [in Turkish]
  • Aydın AN, Aydın R, Serdar O. 2022. Determination of Letal Concentrations (LC50) of Cyfluthrın, Dimethoate Insecticides on Gammarus pulex (L., 1758). Acta Aquatica Turcica. 18(3):384-392. doi: 10.22392/actaquatr.1080270
  • Aydın AN, Serdar O. 2024a. Effect of Probiotic on Copper Nanoparticle Accumulation in Dreissena polymorpha. Journal of Limnology and Freshwater Fisheries Research. 10(1):39-46. doi: 10.17216/limnofish.1272399
  • Aydın AN, Serdar O. 2024b. Terbiyumun Pontastacus leptodactylus’ta ki Oksidatif Stres ve Antioksidan Yanıtlarının Belirlenmesi. Acta Aquatica Turcica. 20(1):23-32. doi: 10.22392/actaquatr.1294250 [in Turkish]
  • Baratange C, Paris-Palacios S, Bonnard I, Delahaut L, Grandjean D, Wortham L, Sayen S, Gallorini A, Michel J, Renault D, Breider F, Loizeau JL, Cosio C. 2022. Metabolic, cellular and defense responses to single and co-exposure to carbamazepine and methylmercury in Dreissena polymorpha. Environ Pollut. 300(11):118933. doi: 10.1016/j.envpol.2022.118933
  • Benjamin KB, Co EL, Competente JL, De Guzman DGH. 2019. Histopathological effects of bisphenol A on soft tissues of Corbicula fluminea Mull. Toxicol Environ Health Sci. 11(1):36-44. doi: 10.1007/s13530-019-0386-4
  • Binelli A, Bacchetta R, Mantecca P, Ricciardi F, Provini A, Vailati G. 2004. DDT in zebra mussels from Lake Maggiore (N. Italy): level of contamination and endocrine disruptions. Aquat Toxicol. 69(2):175-188. doi: 10.1016/j.aquatox.2004.05.005
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  • Cheung CCC, Siu WHL, Richardson BJ, De Luca-Abbott SB, Lam PKS. 2004. Antioxidant responses to benzo[α]pyrene and Aroclor 1254 exposure in the green-lipped mussel, Perna viridis. Environ Pollut. 128(3):393-403. doi: 10.1016/j.envpol.2003.09.010
  • Cnubben NHP, Rietjens IMCM, Wortelboer H, van Zanden J, van Bladeren PJ. 2001. The interplay of glutathione-related processes in antioxidant defense. Environ Toxicol Phar. 10(4):141-152. doi: 10.1016/S1382-6689(01)00077-1
  • Connon RE, Geist J, Werner I. 2012. Effect-based tools for monitoring and predicting the ecotoxicological effects of chemicals in the aquatic environment. Sensors. 12(9):12741-12771. doi: 10.3390/s120912741
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Determination of Toxic Effect of Gamma Cyhalothrin in Dreissena polymorpha by Some Biomarkers

Yıl 2025, Cilt: 11 Sayı: 1, 20 - 32, 30.04.2025

Ayşe Nur Aydın , Osman Serdar , Tuba Parlak Ak

https://doi.org/10.17216/limnofish.1556682

Öz

In this study, the effects of pesticides on the freshwater mussel Dreissena polymorpha, a non-target organism, were aimed to be determined through biochemical responses. For this purpose, first, the acute toxicity value (LC50) of Gamma Cyhalothrin (GCH) pesticide on D. polymorpha was determined by standard static method and the LC50 value was calculated as 13.64 mg/L using probit analysis. Then, superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activities, malondialdehyde (MDA) and glutathione (GSH) level responses of D. polymorpha organism exposed to GCH sublethal concentrations for 24 and 96 hours were determined. In addition to biochemical biomarkers, histopathological responses were evaluated. In conclusion, this study demonstrated the abilities of GCH pesticides to induce oxidative stress. Moreover, MDA, GSH levels, SOD, CAT, GPx activities and histopathological responses could be used as an effective biomarker in D. polymorpha.

Anahtar Kelimeler

Dreissena polymorpha gamma cyhalothrin biomarker oxidative stress histology

Kaynakça

  • Altıkat A, Turan T, Ekmekyapar Torun F, Bingül Z. 2009. Türkiye’de Pestisit Kullanımı ve Çevreye Olan Etkileri. Atatürk Üniv Ziraat Fak Derg. 40(2):87-92. [in Turkish]
  • Aydın AN, Aydın R, Serdar O. 2022. Determination of Letal Concentrations (LC50) of Cyfluthrın, Dimethoate Insecticides on Gammarus pulex (L., 1758). Acta Aquatica Turcica. 18(3):384-392. doi: 10.22392/actaquatr.1080270
  • Aydın AN, Serdar O. 2024a. Effect of Probiotic on Copper Nanoparticle Accumulation in Dreissena polymorpha. Journal of Limnology and Freshwater Fisheries Research. 10(1):39-46. doi: 10.17216/limnofish.1272399
  • Aydın AN, Serdar O. 2024b. Terbiyumun Pontastacus leptodactylus’ta ki Oksidatif Stres ve Antioksidan Yanıtlarının Belirlenmesi. Acta Aquatica Turcica. 20(1):23-32. doi: 10.22392/actaquatr.1294250 [in Turkish]
  • Baratange C, Paris-Palacios S, Bonnard I, Delahaut L, Grandjean D, Wortham L, Sayen S, Gallorini A, Michel J, Renault D, Breider F, Loizeau JL, Cosio C. 2022. Metabolic, cellular and defense responses to single and co-exposure to carbamazepine and methylmercury in Dreissena polymorpha. Environ Pollut. 300(11):118933. doi: 10.1016/j.envpol.2022.118933
  • Benjamin KB, Co EL, Competente JL, De Guzman DGH. 2019. Histopathological effects of bisphenol A on soft tissues of Corbicula fluminea Mull. Toxicol Environ Health Sci. 11(1):36-44. doi: 10.1007/s13530-019-0386-4
  • Binelli A, Bacchetta R, Mantecca P, Ricciardi F, Provini A, Vailati G. 2004. DDT in zebra mussels from Lake Maggiore (N. Italy): level of contamination and endocrine disruptions. Aquat Toxicol. 69(2):175-188. doi: 10.1016/j.aquatox.2004.05.005
  • Brooks ML, Fleishman E, Brown LR, Lehman PW, Werner I, Scholz N, Mitchelmore C, Lovvorn JR, Johnson ML, Schlenk D, van Drunick S, Drever JI, Stoms DM, Parker AE, Dugdale R. 2012. Life histories, salinity zones, and sublethal contributions of contaminants to pelagic fish declines illustrated with a case study of San Francisco Estuary, California, USA. Estuar Coasts. 35(2):603-621. doi: 10.1007/s12237-011-9459-6
  • Chen M, Zhou J, Lin J, Tang H, Shan Y, Chang AK, Ying X. 2020. Changes in oxidative stress biomarkers in Sinonovacula constricta in response to toxic metal accumulation during growth in an aquaculture farm. Chemosphere. 248(8):125974. doi: 10.1016/j.chemosphere.2020.125974
  • Cheung CCC, Siu WHL, Richardson BJ, De Luca-Abbott SB, Lam PKS. 2004. Antioxidant responses to benzo[α]pyrene and Aroclor 1254 exposure in the green-lipped mussel, Perna viridis. Environ Pollut. 128(3):393-403. doi: 10.1016/j.envpol.2003.09.010
  • Cnubben NHP, Rietjens IMCM, Wortelboer H, van Zanden J, van Bladeren PJ. 2001. The interplay of glutathione-related processes in antioxidant defense. Environ Toxicol Phar. 10(4):141-152. doi: 10.1016/S1382-6689(01)00077-1
  • Connon RE, Geist J, Werner I. 2012. Effect-based tools for monitoring and predicting the ecotoxicological effects of chemicals in the aquatic environment. Sensors. 12(9):12741-12771. doi: 10.3390/s120912741
  • Costa CR, Olivi P, Botta CMR, Espindola ELG. 2008. A toxicidade em ambientes aquáticos: discussão e métodos de avaliação. Quím Nova. 31(7):1820-1830. doi: 10.1590/S0100-40422008000700038 [in Portuguese]
  • Dethe VD, Ahire PB. 2023. Evaluation of Imidacloprid-induced toxicity and lipid peroxidation in the freshwater bivalve, Lamellidens marginalis. International Journal of Aquatic Biology. 11(2):124-130. doi: 10.22034/ijab.v11i2.1902
  • Dickinson DA, Forman HJ. 2002. Glutathione in defense and signaling: lessons from a small thiol. Ann NY Acad Sci. 973(1):488-504. doi: 10.1111/j.1749-6632.2002.tb04690.x
  • FAO 2009. Food and Agriculture Organization of the United Nations. World summit on food security 16-18 November 2009; [cited 2023 Aug 15]. Available from https://www.fao.org/fileadmin/templates/wsfs/Summit/Docs/Declaration/WSFS09_Draft_Declaration.pdf
  • Faria M, Carrasco L, Diez S, Riva MC, Bayona JM, Barata C. 2009. Multi-biomarker responses in the freshwater mussel Dreissena polymorpha exposed to polychlorobiphenyls and metals. Comp Biochem Phys C. 149(3):281-288. doi: 10.1016/j.cbpc.2008.07.012
  • Ferrari A, Venturino A, de D’Angelo AMP. 2007. Effects of carbaryl and azinphos methyl on juvenile rainbow trout (Oncorhynchus mykiss) detoxifying enzymes. Pestic Biochem Phys. 88(2):134-142. doi: 10.1016/j.pestbp.2006.10.005
  • Fisher SW, Stromberg P, Bruner KA, Boulet LD. 1991. Molluscicidal activity of potassium to the zebra mussel, Dreissena polymorphia: toxicity and mode of action. Aquat Toxicol. 20(4):219-234. doi: 10.1016/0166-445X(91)90061-D
  • Florencio T, Carraschi SP, da Cruz C, da Silva AF, Marques AM, Pitelli RA. 2014. Neotropical bioindicators of ecotoxicity and environmental risk of drugs with aquaculture interest. Bol Inst Pesca. 40(4):569-576. [in Portuguese]
  • Florescu IE, Georgescu SE, Dudu A, Balaș M, Voicu S, Grecu I, Dediu L, Dinischiotu A, Costache M. 2021. Oxidative stress and antioxidant defense mechanisms in response to starvation and refeeding in the intestine of stellate sturgeon (Acipenser stellatus) juveniles from aquaculture. Animals. 11(1):1-20. doi: 10.3390/ani11010076
  • Geist J. 2011. Integrative freshwater ecology and biodiversity conservation. Ecol Indic. 11(6):1507-1516. doi: 10.1016/j.ecolind.2011.04.002
  • Geoffroy L, Frankart C, Eullaffroy P. 2004. Comparison of different physiological parameter responses in Lemna minor and Scenedesmus obliquus exposed to herbicide flumioxazin. Environ Pollut. 131(2):233-241. doi: 10.1016/j.envpol.2004.02.021
  • Giamberini L, Guerold F, Beauvais MN, Pihan JC. 1996. Histopathological effects of an organic molluscicide on the gills of the zebra mussel: Ultrastructural study. Toxicol Environ Chem. 57(1-4):27-35. doi: 10.1080/02772249609358374
  • Greco L, Pellerin J, Capri E, Garnerot F, Louis S, Fournier M, Sacchi A, Fusi M, Lapointe D, Couture P. 2011. Physiological effects of temperature and a herbicide mixture on the soft-shell clam Mya arenaria (Mollusca, Bivalvia). Environ Toxicol Chem. 30(1):132-141. doi: 10.1002/etc.359
  • Hao L, Wang Z, Xing B. 2009. Effect of sub-acute exposure to TiO2 nanoparticles on oxidative stress and histopathological changes in Juvenile Carp (Cyprinus carpio), J Environ Sci. 21(10):1459-1466. doi: 10.1016/S1001-0742(08)62440-7
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  • Kaya H, Selvi K, Akbulut M, Duysak M, Aydın F. 2013. Kirli ve Temiz Bölgelerden Toplanan Dreissena polymorpha Bireylerinde Ağır Metal Birikimi ve Oksidatif Stres Duyarlılığının Belirlenmesi. Menba Kastamonu Üniversitesi Su Ürünleri Fakültesi Dergisi. 1(2):9-14. [in Turkish]
  • Kono Y, Fridovich I. 1982. Superoxide radical inhibits catalase. J Biol Chem. 257(10):5751-5754. doi: 10.1016/S0021-9258(19)83842-5
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  • Lakhani L. 2015. How to reduce impact of pesticides in aquatic environment. International Journal of Research - Granthaalayah. 3(9 Special Edition):1-5. doi: 10.29121/granthaalayah.v3.i9SE.2015.3199
  • Lew S, Lew M, Szarek J, Mieszczyński T. 2009. Effect of Pesticides on Soil and Aquatic Environmental Microorganisms - A Short Review. Fresen Environ Bull. 18(8):1390-1395.
  • Liang Z, Liu R, Zhao D, Wang L, Sun M, Wang M, Song L. 2016. Ammonia exposure induces oxidative stress, endoplasmic reticulum stress and apoptosis in hepatopancreas of pacific white shrimp (Litopenaeus vannamei). Fish Shellfish Immun. 54(1):523-528. doi: 10.1016/j.fsi.2016.05.009
  • Livingstone DR. 2003. Oxidative stress in aquatic organisms in relation to pollution and aquaculture. Rev Med Vet-Toulouse. 154(6):427-430.
  • Magara G, Sangsawang A, Pastorino P, Oddon SB, Caldaroni B, Menconi V, Kovitvadhi U, Gasco L, Meloni D, Dörr AJM, Prearo M, Federici E, Elia AC. 2021. First insights into oxidative stress and theoretical environmental risk of Bronopol and Detarox® AP, two biocides claimed to be ecofriendly for a sustainable aquaculture. Sci Total Environ. 778:146375. doi: 10.1016/j.scitotenv.2021.146375
  • Magra GC, Saperdi AJ, Ferreras LA. 2021. Diagnosticar Las Reservas De Agua Útil: Una Herramienta Para La Toma De Decisiones Y Potenciar La Rentabilidad Económica Del Cultivo De Trigo. Revista Americana De Empreendedorismo E Inovação. 3(2):7-18. [in Spanish]
  • Mantecca P, Vailati G, Bacchetta R. 2006. Histological changes and Micronucleus induction in the Zebra mussel Dreissena polymorpha after Paraquat exposure. Histol Histopathol. 21(8):829-840. doi: 10.14670/HH-21.829
  • McCord JM. 1996. Effects of positive iron status at a cellular level. Nutr Rev. 54(3):85-88. doi: 10.1111/j.1753-4887.1996.tb03876.x
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  • Moreira AMS, Freitas ETF, Reis MDP, Nogueira JM, Barbosa NPDU, Reis ALM, Pelli A, Camargo PRDS, Cardoso AV, de Paula RS, Jorge EC. 2023. Acute Exposure to Two Biocides Causes Morphological and Molecular Changes in the Gill Ciliary Epithelium of the Invasive Golden Mussel Limnoperna fortunei (Dunker, 1857). Animals. 13(20):1-19. doi: 10.3390/ani13203258
  • National Center for Biotechnology Information 2024. PubChem Compound Summary for CID 71464055, Gama-cyhalothrin; [cited 2024 Aug 08]. Available from ttps://pubchem.ncbi.nlm.nih.gov/compound/Gama-cyhalothrin
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  • Tutuş R. 2016. Oreochromis niloticus’ un karaciğer dokusundaki antioksidan sistemler ve lipid peroksidasyonu üzerine chlorpyrifos, emamectin benzoate ve abamectin türü pestisitlerin etkileri [Master's Thesis]. Adıyaman University. 100 p. [in Turkish]
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  • Yancheva V, Velcheva I, Iliev I, Vasileva T, Bivolarski V, Georgieva E, Stoyanova S. 2020. Histochemical and Biochemical Alterations in Zebra Mussel Dreissena polymoprha (Pallas, 1771) after Cadmium and Polyaromatic Hydrocarbons Exposure. Acta Zool Bulgar. 15:155-164.
  • Yang SJ, Lee JE, Lee KH, Huh JW, Choi SY, Cho SW. 2004. Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains. Mol Brain Res. 127(1-2):146-149. doi: 10.1016/j.molbrainres.2004.05.016
  • Yuksel F, Aydin R, Serdar O, Pala A. 2020. Examining the biochemical effect of malathion pesticide on Gammarus pulex (L., 1798). Fresen Environ Bull. 29(10):9490-9497.
Toplam 60 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Tatlı Su Ekolojisi, Ekotoksikoloji, Kabuklu Su Ürünleri Yetiştiriciliği
Bölüm Araştırma Makalesi
Yazarlar

Ayşe Nur Aydın 0000-0002-5657-8958

Osman Serdar 0009-0009-0110-8789

Tuba Parlak Ak 0000-0002-8318-7995

Erken Görünüm Tarihi 28 Nisan 2025
Yayımlanma Tarihi 30 Nisan 2025
Gönderilme Tarihi 8 Ekim 2024
Kabul Tarihi 25 Mart 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 11 Sayı: 1

Kaynak Göster

APA Aydın, A. N., Serdar, O., & Parlak Ak, T. (2025). Determination of Toxic Effect of Gamma Cyhalothrin in Dreissena polymorpha by Some Biomarkers. Journal of Limnology and Freshwater Fisheries Research, 11(1), 20-32. https://doi.org/10.17216/limnofish.1556682
 Kapak Resmi İndir