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Determination of Toxic Effect of Gamma Cyhalothrin in Dreissena polymorpha by Some Biomarkers

Year 2025, , 20 - 32, 30.04.2025

Ayşe Nur Aydın , Osman Serdar , Tuba Parlak Ak

https://doi.org/10.17216/limnofish.1556682

Abstract

In this study, the effects of pesticides on the freshwater mussel Dreissena polymorpha, a non-target organism, were aimed to be determined through biochemical responses. For this purpose, first, the acute toxicity value (LC50) of Gamma Cyhalothrin (GCH) pesticide on D. polymorpha was determined by standard static method and the LC50 value was calculated as 13.64 mg/L using probit analysis. Then, superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activities, malondialdehyde (MDA) and glutathione (GSH) level responses of D. polymorpha organism exposed to GCH sublethal concentrations for 24 and 96 hours were determined. In addition to biochemical biomarkers, histopathological responses were evaluated. In conclusion, this study demonstrated the abilities of GCH pesticides to induce oxidative stress. Moreover, MDA, GSH levels, SOD, CAT, GPx activities and histopathological responses could be used as an effective biomarker in D. polymorpha.

Keywords

Dreissena polymorpha gamma cyhalothrin biomarker oxidative stress histology

References

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Gamma Cyhalothrin’in Dreissena polymorpha’daki Toksik Etkisinin Bazı Biyobelirteçlerle Belirlenmesi

Year 2025, , 20 - 32, 30.04.2025

Ayşe Nur Aydın , Osman Serdar , Tuba Parlak Ak

https://doi.org/10.17216/limnofish.1556682

Abstract

Bu çalışmada, pestisitlerin hedef olmayan organizmalar olan tatlı su midyesi Dreissena polymorpha üzerindeki etkilerinin biyokimyasal tepkilerle belirlenmesi amaçlandı. Bu amaçla öncelikle Gamma Cyhalothrin (GCH) pestisitinin D. polymorpha üzerindeki akut toksisite değeri (LC50) standart statik yöntemle belirlenmiş ve probit analizi ile 13,64 mg/L hesaplanmıştır. Daha sonra 24 ve 96 saat boyunca ölümcül olmayan GCH konsantrasyonlarına maruz kalan D. polymorpha türünün süperoksit dismutaz (SOD), glutatyon peroksidaz (GPx), katalaz (CAT) aktiviteleri, malondialdehit (MDA) ve glutatyon (GSH) düzeyi tepkileri belirlendi. Biyokimyasal biyobelirteçlerin yanı sıra histopatolojik yanıtlar da değerlendirildi. Sonuç olarak, bu çalışma GCH pestisitlerinin oksidatif stresi tetikleme yeteneklerini ortaya koydu. Ayrıca MDA, GSH düzeyleri, SOD, CAT, GPx aktiviteleri ve histopatolojik yanıtlar da D. polymorpha'da etkili bir biyobelirteç olarak kullanılabilir.

Keywords

Dreissena polymorpha gamma cyhalothrin biyobelirteç oksidatif stres histoloji

References

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  • Aydın AN, Serdar O. 2024a. Effect of Probiotic on Copper Nanoparticle Accumulation in Dreissena polymorpha. Journal of Limnology and Freshwater Fisheries Research. 10(1):39-46. doi: 10.17216/limnofish.1272399
  • Aydın AN, Serdar O. 2024b. Terbiyumun Pontastacus leptodactylus’ta ki Oksidatif Stres ve Antioksidan Yanıtlarının Belirlenmesi. Acta Aquatica Turcica. 20(1):23-32. doi: 10.22392/actaquatr.1294250 [in Turkish]
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  • Benjamin KB, Co EL, Competente JL, De Guzman DGH. 2019. Histopathological effects of bisphenol A on soft tissues of Corbicula fluminea Mull. Toxicol Environ Health Sci. 11(1):36-44. doi: 10.1007/s13530-019-0386-4
  • Binelli A, Bacchetta R, Mantecca P, Ricciardi F, Provini A, Vailati G. 2004. DDT in zebra mussels from Lake Maggiore (N. Italy): level of contamination and endocrine disruptions. Aquat Toxicol. 69(2):175-188. doi: 10.1016/j.aquatox.2004.05.005
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  • Cnubben NHP, Rietjens IMCM, Wortelboer H, van Zanden J, van Bladeren PJ. 2001. The interplay of glutathione-related processes in antioxidant defense. Environ Toxicol Phar. 10(4):141-152. doi: 10.1016/S1382-6689(01)00077-1
  • Connon RE, Geist J, Werner I. 2012. Effect-based tools for monitoring and predicting the ecotoxicological effects of chemicals in the aquatic environment. Sensors. 12(9):12741-12771. doi: 10.3390/s120912741
  • Costa CR, Olivi P, Botta CMR, Espindola ELG. 2008. A toxicidade em ambientes aquáticos: discussão e métodos de avaliação. Quím Nova. 31(7):1820-1830. doi: 10.1590/S0100-40422008000700038 [in Portuguese]
  • Dethe VD, Ahire PB. 2023. Evaluation of Imidacloprid-induced toxicity and lipid peroxidation in the freshwater bivalve, Lamellidens marginalis. International Journal of Aquatic Biology. 11(2):124-130. doi: 10.22034/ijab.v11i2.1902
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  • Ferrari A, Venturino A, de D’Angelo AMP. 2007. Effects of carbaryl and azinphos methyl on juvenile rainbow trout (Oncorhynchus mykiss) detoxifying enzymes. Pestic Biochem Phys. 88(2):134-142. doi: 10.1016/j.pestbp.2006.10.005
  • Fisher SW, Stromberg P, Bruner KA, Boulet LD. 1991. Molluscicidal activity of potassium to the zebra mussel, Dreissena polymorphia: toxicity and mode of action. Aquat Toxicol. 20(4):219-234. doi: 10.1016/0166-445X(91)90061-D
  • Florencio T, Carraschi SP, da Cruz C, da Silva AF, Marques AM, Pitelli RA. 2014. Neotropical bioindicators of ecotoxicity and environmental risk of drugs with aquaculture interest. Bol Inst Pesca. 40(4):569-576. [in Portuguese]
  • Florescu IE, Georgescu SE, Dudu A, Balaș M, Voicu S, Grecu I, Dediu L, Dinischiotu A, Costache M. 2021. Oxidative stress and antioxidant defense mechanisms in response to starvation and refeeding in the intestine of stellate sturgeon (Acipenser stellatus) juveniles from aquaculture. Animals. 11(1):1-20. doi: 10.3390/ani11010076
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  • Giamberini L, Guerold F, Beauvais MN, Pihan JC. 1996. Histopathological effects of an organic molluscicide on the gills of the zebra mussel: Ultrastructural study. Toxicol Environ Chem. 57(1-4):27-35. doi: 10.1080/02772249609358374
  • Greco L, Pellerin J, Capri E, Garnerot F, Louis S, Fournier M, Sacchi A, Fusi M, Lapointe D, Couture P. 2011. Physiological effects of temperature and a herbicide mixture on the soft-shell clam Mya arenaria (Mollusca, Bivalvia). Environ Toxicol Chem. 30(1):132-141. doi: 10.1002/etc.359
  • Hao L, Wang Z, Xing B. 2009. Effect of sub-acute exposure to TiO2 nanoparticles on oxidative stress and histopathological changes in Juvenile Carp (Cyprinus carpio), J Environ Sci. 21(10):1459-1466. doi: 10.1016/S1001-0742(08)62440-7
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There are 60 citations in total.

Details

Primary Language English
Subjects Freshwater Ecology, Ecotoxicology, Shellfish Culture
Journal Section Research Article
Authors

Ayşe Nur Aydın 0000-0002-5657-8958

Osman Serdar 0009-0009-0110-8789

Tuba Parlak Ak 0000-0002-8318-7995

Early Pub Date April 28, 2025
Publication Date April 30, 2025
Submission Date October 8, 2024
Acceptance Date March 25, 2025
Published in Issue Year 2025

Cite

APA Aydın, A. N., Serdar, O., & Parlak Ak, T. (2025). Determination of Toxic Effect of Gamma Cyhalothrin in Dreissena polymorpha by Some Biomarkers. Journal of Limnology and Freshwater Fisheries Research, 11(1), 20-32. https://doi.org/10.17216/limnofish.1556682