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Ameliorative Effect of Jamaican Cherry (Muntingia calabura L.) Leaf Extract Toward Glucose Control and Immune Cells Modulation in High Fat Diet-Administrated Mice

Yıl 2024, Cilt: 34 Sayı: 1, 1 - 13, 31.03.2024

Wira Eka Putra Intan Nilatus Shofiyah Adelia Riezka Rahim Arief Hidayatullah Muhaimin Rifa’i

https://doi.org/10.29133/yyutbd.1331257

Öz

Hyperglycemia is a dangerous condition in which too much glucose circulates in the blood plasma and is the leading cause of diabetes mellitus. It is a complex condition with varying degrees that can change over time, mainly owing to metabolic factors that reduce insulin secretion, decrease glucose use, and increase glucose production. This study aims to evaluate Muntingia calabura leaf extract's effect on glucose control and immune cell modulation in high-fat diet-administrated mice. According to the result, we found that M. calabura leaf extract significantly reduced the fasting blood sugar. Importantly, M. calabura leaf extract exerts immunomodulation effects by suppressing the relative number of regulatory T cells in the hypoglycemic mice model. Finally, this study showed M. calabura leaf extract exerts ameliorative potency against hyperglycemia by lowering the blood sugar level and suppressing the regulatory T cells. These results suggested that M. calabura leaf extract could develop into complementary and alternative medicine.

Anahtar Kelimeler

Blood sugar level high fat diet immune system insulin M. calabura

Kaynakça

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  • Abideen, Z. U., Mahmud, S. N., Rasheed, A., Farooq, Q. Y., & Ali, F. (2017). Central diabetes insipidus and hyperglycemic hyperosmolar state following accidental carbon monoxide poisoning. Cureus, 9(6), 1-6. doi: 10.7759/cureus.1305.
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  • Barnett, R. 2018. Type 1 diabetes. Lancet, 391(10117), 195-195. doi: 10.1016/S0140-6736(18)30024-2.
  • Basu, M., Pandit, K., Banerjee, M., Mondal, S. A., Mukhopadhyay, P., & Ghosh, S. (2020). Profile of auto-antibodies (disease related and other) in children with type 1 diabetes. Indian Journal of Endocrinology and Metabolism, 24(3), 256–259. doi: 10.4103/ijem.IJEM_63_20.
  • Budi, E. H., Muthusamy, B. P., & Derynck, R. (2015). The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors. Science Signaling, 8(396), 1–37. doi: 10.1126/scisignal.aaa9432.
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Yıl 2024, Cilt: 34 Sayı: 1, 1 - 13, 31.03.2024

Wira Eka Putra Intan Nilatus Shofiyah Adelia Riezka Rahim Arief Hidayatullah Muhaimin Rifa’i

https://doi.org/10.29133/yyutbd.1331257

Öz

Kaynakça

  • Abdelkader, N. F., Eitah, H. E., Maklad, Y. A, Gamaleldin, A. A, Badawi, M. A., & Kenawy, S. A. (2020). New combination therapy of gliclazide and quercetin for protection against STZ-induced diabetic rats. Life Sciences, 247(117458), 1-9. doi: 10.1016/j.lfs.2020.117458.
  • Abideen, Z. U., Mahmud, S. N., Rasheed, A., Farooq, Q. Y., & Ali, F. (2017). Central diabetes insipidus and hyperglycemic hyperosmolar state following accidental carbon monoxide poisoning. Cureus, 9(6), 1-6. doi: 10.7759/cureus.1305.
  • Ahn, K. (2017). The worldwide trend of using botanical drugs and strategies for developing global drugs. BMB Reports, 50(3), 111–116. doi: 10.5483/bmbrep.2017.50.3.221.
  • Alam, W., Khan, H., Shah, M. A., Cauli, O., & Saso, L. (2020). Kaempferol as a dietary anti-inflammatory agent: Current therapeutic standing. Molecules, 25(18), 1–13. doi: 10.3390/molecules25184073.
  • American Diabetes Association Professional Practice Committee. (2021). Classification and diagnosis of diabetes: Standards of medical care in diabetes—2022. Diabetes Care, 45(1), 17–38. doi: 10.2337/dc22-S002.
  • Barnett, R. 2018. Type 1 diabetes. Lancet, 391(10117), 195-195. doi: 10.1016/S0140-6736(18)30024-2.
  • Basu, M., Pandit, K., Banerjee, M., Mondal, S. A., Mukhopadhyay, P., & Ghosh, S. (2020). Profile of auto-antibodies (disease related and other) in children with type 1 diabetes. Indian Journal of Endocrinology and Metabolism, 24(3), 256–259. doi: 10.4103/ijem.IJEM_63_20.
  • Budi, E. H., Muthusamy, B. P., & Derynck, R. (2015). The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors. Science Signaling, 8(396), 1–37. doi: 10.1126/scisignal.aaa9432.
  • Chaudhury, A., Duvoor, C., Reddy, D. V. S., Kralet, S., Chada, A., Ravilla, R., Marco, A., Shekhawat, N. S., Montales, M. T., Kuriakose, K., Sasapu, A., Beebe, A., & Mirza, W. (2017). Clinical review of antidiabetic drugs: Implications for type 2 diabetes mellitus management. Frontiers in Endocrinology, 8(6), 1–12. doi: 10.3389/fendo.2017.00006.
  • Chen, H-Y., Ho, Y-J., & Chan, H-L. (2020). The role of transforming growth factor-beta in retinal ganglion cells with hyperglycemia and oxidative stress. International Journal of Molecular Sciences, 21(18), 1-21. doi: 10.3390/ijms21186482.
  • Chen, L., Chen, R., Wang, H., & Liang, F. (2015). Mechanisms linking inflammation to insulin resistance. International Journal of Endocrinology, 2015(508409), 1–9. doi: 10.1155/2015/508409.
  • Das, D., Sarkar, S., & Manna, P. (2018). Daidzein, its effects on impaired glucose and lipid metabolism and vascular inflammation associated with type 2 diabetes. BioFactors, 44(5), 407–417. doi: 10.1002/biof.1439.
  • Den Hartogh, D. J., Gabriel, A., & Tsiani, E. (2020). Antidiabetic properties of curcumin I: Evidence from in vitro studies. Nutrients, 12(1), 1–32. doi: 10.3390/nu12010118.
  • Dhanya, R. (2022). Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy. Biomedicine & Pharmacotherapy, 146(112560), 1–7. doi: 10.1016/j.biopha.2021.112560.
  • Dhawan, S., Dirice, E., Kulkarni, R. N., & Bhushan, A. (2016). Inhibition of TGF-β signaling promotes human pancreatic β-cell replication. Diabetes, 65(5), 1208–1218. doi: 10.2337/db15-1331.
  • Eguchi, N., Vaziri, N. D., Dafoe, D. C., & Ichii, H. (2021). The role of oxidative stress in pancreatic β cell dysfunction in diabetes. International Journal of Molecular Sciences, 22(4), 1–18. doi: 10.3390/ijms22041509.
  • El-Far, Y. M., Khodir, A. E., Emarah, Z. A., Ebrahim, M. A., & Al-Gayyar, M. M. H. (2022). Chemopreventive and hepatoprotective effects of genistein via inhibition of oxidative stress and the versican/PDGF/PKC signaling pathway in experimentally induced hepatocellular carcinoma in rats by thioacetamide. Redox Report, 27(1), 9–20. doi: 10.1080/13510002.2022.2031515.
  • Ellulu, M. S., Patimah, I., Khaza’a, H., Rahmat, A., & Abed, Y. (2017). Obesity and inflammation: The linking mechanism and the complications. Archieves of Medical Science, 13(4), 851–863. doi: 10.5114/aoms.2016.58928.
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  • Kanatsuka, A., Kou, S., & Makino, H. (2018). IAPP/amylin and β-cell failure: Implication of the risk factors of type 2 diabetes. Diabetology International, 9(3), 143–157. doi: 10.1007/s13340-018-0347-1.
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  • Kobori, M., Takahashi, Y., & Ippoushi, K. (2016). Quercetin suppresses immune cell accumulation and improves mitochondrial gene expression in adipose tissue of diet‐induced obese mice. Molecular Nutrition & Food Research, 60(2), 300–312. doi: 10.1002/mnfr.201500595.
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  • Lee, J-H., Lee, J-H., & Rane, S. G. (2021). TGF-β Signaling in pancreatic islet β cell development and function. Endocrinology, 162(3), 1–10. doi: 10.1210/endocr/bqaa233.
  • Leyva-López, N., Gutierrez-Grijalva, E. P., Ambriz-Perez, D. L., & Heredia, J. B. (2016). Flavonoids as cytokine modulators: A possible therapy for inflammation-related diseases. International Journal of Molecular Science, 17(6), 1–15. doi: 10.3390/ijms17060921.
  • Lin, F., Luo, X., & Li, B. (2015). Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation. International Immunopharmacology, 28(2), 859–865. doi: 10.1016/j.intimp.2015.03.044.
  • Longo, M., Zatterale, F., & Miele, C. (2019). Adipose tissue dysfunction as determinant of obesity-associated metabolic complications. International Journal of Molecular Sciences, 20(9), 1–23. doi: 10.3390/ijms20092358.
  • Maffettone, A., Rinaldi, M., & Fontanella, A. (2018). Postprandial hyperglycemia: A new frontier in diabetes management? Italian Journal of Medicine, 12(2018), 108–115. doi: 10.4081/itjm.2018.961.
  • Meng, L., Jin, W., & Wang, X. (2015). RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality. Proceedings of the National Academy of Sciences, 112(35), 11007–11012. doi: 10.1073/pnas.1514730112.
  • Noipha, K., & Ninla-Aesong, P. (2018). Antidiabetic activity of Zingiber officinale Roscoe rhizome extract: An in vitro study. HAYATI Journal of Biosciences, 25(4), 1-9. doi: 10.4308/hjb.25.4.160.
  • Nurcholis, W., Iqbal, T. M., Sulistiyani, S., & Liwanda, N. (2023). Profile of secondary metabolites in different parts of the butterfly pea (Clitoria ternatea) plant with antioxidant activity. Yuzuncu Yil University Journal of Agricultural Sciences, 3(2), 231-247. doi: https://doi.org/10.29133/yyutbd.1251495.
  • Ola, M. S. (2021). Does hyperglycemia cause oxidative stress in the diabetic rat retina? Cells, 10(4), 1–15. doi: 10.3390/cells10040794.
  • Ormazabal, V., Nair, S., & Zuñiga, F. 2018. Association between insulin resistance and the development of cardiovascular disease. Cardiovascular Diabetology, 17(1), 1–14. doi: 10.1186/s12933-018-0762-4.
  • Putra, W. E., & Rifa’i, M. (2019). Immunomodulatory activities of Sambucus javanica extracts in DMBA exposed BALB/c mouse. Advanced Pharmaceutical Bulletin, 9(4), 619-623. doi: https://doi.org/10.15171/apb.2019.071.
  • Putra, W. E., & Rifa’i, M. (2020). Assessing the immunomodulatory activity of ethanol extract of Sambucus javanica berries and leaf in chloramphenicol-induced aplastic anemia mouse model. Tropical Life Science Research, 31(2), 175–185. doi: 10.21315/tlsr2020.31.2.9.
  • Putra, W. E., Agusinta, A. K., Ashar, M. S. A. A., Manullang, V. A., & Rifa'i, M. (2023). Immunomodulatory and ameliorative effect of Citrus limon extract on DMBA‐induced breast cancer in mouse. Karbala International Journal of Modern Science, 9(2), 1-14. doi: 10.33640/2405-609X.3273.
  • Putra, W. E., Maulana, A. R., Ramadhan, A. T. K., & Rifa’i, M. (2020). T cells regulation modulated by Sambucus javanica extracts in DMBA-exposed mice. Journal of Herbmed Pharmacology, 9(4), 408-411. doi: https://doi.org/10.34172/jhp.2020.51.
  • Putra, W. E., Soewondo, A., & Rifa’i, M. (2016). Effect of dexamethasone administration toward hematopoietic stem cells and blood progenitor cells expression on BALB/c mice. Journal of Pure and Applied Chemistry Research, 4(3), 100-108. doi: 10.21776/ub.jpacr.2015.004.03.221.
  • Putra, W. E., Soewondo, A., & Rifa'i, M. (2015). Expression of erythroid progenitor cells and erythrocytes on dexamethasone induced-mice. Biotropika, 3(1), 42-45.
  • Putra, W. E., Waffareta, E., Ardiana, O., Januarisasi, I. D., Soewondo, A., & Rifa'i, M. (2017). Dexamethasone-administrated BALB/c mouse promotes proinflammatory cytokine expression and reduces CD4+CD25+ regulatory T cells population. Bioscience Research, 14(2), 201-213.
  • Qiao, Y., Shen, J., & Zhao, H. (2016). Changes of regulatory T cells and of proinflammatory and immunosuppressive cytokines in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Journal of Diabetes Research, 2016(694957), 1–19. doi: 10.1155/2016/3694957.
  • Rahayu, S., Rifa'i, M., Qosimah, D., Widyarti, D., Lestari, N. D., Jatmiko, Y. D., Putra, W. E., & Tsuboi, H. (2022). Benefits of Coriandrum sativum L. seed extract in maintaining immunocompetent cell homeostasis. Sains Malaysiana, 51(8), 2425-2434. doi: https://doi.org/10.17576/jsm-2022-5108.
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  • Salvatore, T., Pafundi, P. C., & Adinolfi, L. E. (2019). Metformin lactic acidosis: Should we still be afraid? Diabetes Research and Clinical Practice, 157(107879), 1–31. doi: 10.1016/j.diabres.2019.107879.
  • Saravanan, S., & Pari, L. (2015). Role of thymol on hyperglycemia and hyperlipidemia in high fat diet-induced type 2 diabetic C57BL/6J mice. European Journal of Pharmacology, 761(2015), 279–287. doi: 10.1016/j.ejphar.2015.05.034.
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  • Silver, B., Ramaiya, K., & Makhoba, A. (2018). EADSG guidelines: Insulin therapy in diabetes. Diabetes Therapy, 9(2), 449–492. doi: 10.1007/s13300-018-0384-6.
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  • Zhang, X., Li, J., & Tang, J. (2021). Alleviation of liver dysfunction, oxidative stress, and inflammation underlines the protective effects of polysaccharides from Cordyceps cicadae on high sugar/high fat diet‐induced metabolic syndrome in rats. Chemistry & Biodiversity, 18(5), 1–12. doi: 10.1002/cbdv.202100065.
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  • Zolkeflee, N. K. Z., Ramli, N. S., Azlan, A., & Abas, F. (2022). In vitro anti-diabetic activities and UHPLC-ESI-MS/MS profile of Muntingia calabura leaf extract. Molecules, 27(1), 1–12. doi: 10.3390/molecules27010287.
Toplam 79 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Nükleik Asitlerin ve Proteinlerin Tarımsal Moleküler Mühendisliği
Bölüm Makaleler
Yazarlar

Wira Eka Putra 0000-0003-4831-3869

Intan Nilatus Shofiyah Bu kişi benim 0009-0002-6282-6150

Adelia Riezka Rahim Bu kişi benim 0000-0002-4070-9255

Arief Hidayatullah 0000-0003-1929-3635

Muhaimin Rifa’i Bu kişi benim 0000-0001-5731-2951

Erken Görünüm Tarihi 25 Mart 2024
Yayımlanma Tarihi 31 Mart 2024
Kabul Tarihi 28 Ekim 2023
Yayımlandığı Sayı Yıl 2024 Cilt: 34 Sayı: 1

Kaynak Göster

APA Putra, W. E., Shofiyah, I. N., Rahim, A. R., Hidayatullah, A., vd. (2024). Ameliorative Effect of Jamaican Cherry (Muntingia calabura L.) Leaf Extract Toward Glucose Control and Immune Cells Modulation in High Fat Diet-Administrated Mice. Yuzuncu Yıl University Journal of Agricultural Sciences, 34(1), 1-13. https://doi.org/10.29133/yyutbd.1331257
 Kapak Resmi İndir

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