Objevtive: The aim of the study is to investigate the wound healing and antibacterial activity of terebinth extract and the mixture of terebinth + 3% oxytetracycline in experimental wounds in mice.
Material-Method: The animal material of the study consisted of 18 mice. The animals were divided into 3 groups as control group (group I, n: 6), terebinth group (group II, n: 6), terebinth +oxytetracycline group (group III, n: 6). Wounds with a 1-cm2 diameter were induced on the back of the mice and infected with Staphylococcus aureus ATCC® 25923 reference strain. Treatment protocols of the groups were applied daily. Total aerobic mesophilic bacteria and S. aureus count was performed in the swab samples taken on days 3, 7, and 14 of the healing process.
Results: In the study, it was found that wound healing process was completed the earliest in Group III (mean duration of 15.67±0.609 days), which was followed by Group II (18±0.73) and Group I (24.67±0.919), respectively. The healing period was statistically significantly shorter in Group II and Group III than in Group I (p<0.001). In the evaluation of aerobic mesophilic bacteria and S. aureus load, much less live bacteria were found in Group III compared to the other groups. In addition, the bacteria count in group II, in which terebinth extract was used, was less than that of the control group.
Conclusion: Consequently, it was concluded that the extract of terebinth plant grown in Siirt region reduced the bacterial load in the wound area and accelerated the healing process.
mice wound healing Terebinth extract Oxytetracycline Antibacterial
The current study was approved by Siirt University Experimental Animals Local Ethics Committee with the decision dated 10.02.2017 and numbered 2017/01/21.
Siirt Üniversitesi Bilimsel Araştırmalar Koordinatörlüğü
2017-SIUVET-24
2017-SIUVET-24
Birincil Dil | İngilizce |
---|---|
Konular | Veteriner Cerrahi |
Bölüm | 2024 Volume 8 Number 1 |
Yazarlar | |
Proje Numarası | 2017-SIUVET-24 |
Erken Görünüm Tarihi | 2 Nisan 2024 |
Yayımlanma Tarihi | 1 Nisan 2024 |
Gönderilme Tarihi | 16 Ekim 2023 |
Kabul Tarihi | 21 Aralık 2023 |
Yayımlandığı Sayı | Yıl 2024 Cilt: 8 Sayı: 1 |
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