Dihydro [2,3D] pyridine substituted enaminosulfonamide compounds have been synthesized and their effects on carbonic anhydrase II (hCAII) have been evaluated. Pyrido [2,3 d] pyrimidines were synthesized from barbituric acid derivatives, malonanitrile, aldehyde derivatives in basic condition and then hydrolyzed with hydrochloric acid. The targeted compounds were syn-thesized from amino sulfanilamide, dihydro [2,3D] pyridine compounds, and triethylorthoformate. 1H NMR, 13C NMR, FT-IR and elemental analysis were used for the structural analysis of the compounds. The half maximal inhibitory concentration (IC50) values of the compounds were determined to be between 27.03 and 104.39 μM for hCA II and 19.85-76.64 μM for Ki.
Barbituric acid Carbonic anhydrase II Dihydro 2 3 D pyridine Enaminosulfonamide
Sakarya University Scientific Research Projects Coordination Unit
2012-02-04-033/2016-50-02-002.
Duzce University Scientific and Technological Research Laboratory
2012-02-04-033/2016-50-02-002.
Birincil Dil | İngilizce |
---|---|
Konular | Kimya Mühendisliği |
Bölüm | Araştırma Makalesi |
Yazarlar | |
Proje Numarası | 2012-02-04-033/2016-50-02-002. |
Yayımlanma Tarihi | 1 Şubat 2021 |
Gönderilme Tarihi | 13 Şubat 2020 |
Kabul Tarihi | 24 Aralık 2020 |
Yayımlandığı Sayı | Yıl 2021 Cilt: 25 Sayı: 1 |
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