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BIOLOGICAL ACTIVITY DETERMINATION OF BLACK AND WHITE CHIA SEED EXTRACTS OBTAINED BY DIFFERENT EXTRACTION METHODS

Yıl 2022, Cilt: 46 Sayı: 2, 277 - 290, 29.05.2022

Yasin Darı Süleyman Yur Gülmira Özek Ülkü Dilek Uysal Temel Özek

https://doi.org/10.33483/jfpau.971725

Öz

Objective: Determination and comparison of the biological activities of black and white chia seeds in extracts obtained by different extraction techniques.
Material and Method: Biological activity studies of extracts obtained by different techniques were determined by applying DPPH radical scavenging potential test, TEAC test and ORAC test. In addition, total phenol and flavonoid amounts were determined in methanolic extract samples.
Result and Discussion: In this study, phenol amount was determined as 9.86 mg GAE/g for black seed and 12.69 mg GAE/g for white seed and the total amount of flavonoids was determined as 0.098 mg RE/mL for black chia seed and 0.099 RE/mL for white seed. In addition, considering the antioxidant activity tests, the highest antioxidant activity for TEAC test was found in both black and white seed extracts obtained by the Cold press method, the highest activity for DPPH was in the white seed extracted obtained by the Cold press method, and the highest activity for ORAC test was observed in the white seed extract obtained by the Folch technique.
Keywords: Biological activity, chia, DPPH, ORAC, TEAC

Anahtar Kelimeler

Biological activity chia DPPH ORAC TEAC

Destekleyen Kurum

Eskişehir Technical University Scientific Research Projects

Proje Numarası

Project No: 19ADP063

Teşekkür

The authors are grateful to the Eskişehir Technical University Scientific Research Projects (Project No: 19ADP063) for financial support.

Kaynakça

  • Bochicchio, R., Philips, T. D., Lovelli, S., Labella, R., Galgano, F., Di Marisco, A., . . . Amato, M. (2015). Innovative crop productions for healthy food: the case of chia (Salvia hispanica L.). The sustainability of agro-food and natural resource systems in the Mediterranean basin, 29-45.
  • Hernandez, L. M. (2012). Mucilage from chia seeds (Salvia hispanica): Microestructure, physico-chemical characterization and applications in food industry. Pontificia Universidad Catolica De Chile.
  • Delamare, A. P. L., Moschen-Pistorello, I. T., Artico, L., Atti-Serafini, L., & Echeverrigaray, S. (2007). Antibacterial activity of the essential oils of Salvia officinalis L. and Salvia triloba L. cultivated in South Brazil. Food chemistry, 100(2), 603-608.
  • Kowaleski, J., Quast, L. B., Steffens, J., Lovato, F., dos Santos, L. R., da Silva, S. Z., . Felicetti, M. A. (2020). Functional yogurt with strawberries and chia seeds. Food Bioscience, 37, 100726.
  • Wang, D. H., Wang, Z., Chen, R., Kothapalli, K., & Brenna, J. T. (2020). Very Long-Chain Branched-Chain Fatty Acids in Chia Seeds: Implications for Human Use. Journal of Agricultural and Food Chemistry, 68(47), 13871-13878.
  • del Carmen Beltran-Orozco, M., Martinez-Olguin, A., & del Carmen Robles-Ramirez, M. (2020). Changes in the nutritional composition and antioxidant capacity of chia seeds (Salvia hispanica L.) during germination process. Food Science and Biotechnology, 29(6), 751-757.
  • Mihafu, F. D., Kiage, B. N., Okoth, J. K., & Nyerere, A. K. (2020). Nutritional Composition and Qualitative Phytochemical Analysis of Chia Seeds (Salvia hispanica L.) Grown in East Africa. Current Nutrition and Food Science, 16(6), 988-995.
  • Mihafu, F. D., Kiage, B. N., Kimang’a, A. N., & Okoth, J. K. (2020). Effect of chia seeds (Salvia hispanica) on postprandial glycaemia, body weight and hematological parameters in rats fed a high fat and fructose diet. International Journal of Biological and Chemical Sciences, 14(5), 1752-1762.
  • Güzel, S., Ülger, M., & Yusuf, Ö. (2020). Antimicrobial and Antiproliferative Activities of Chia (Salvia hispanica L.) Seeds. International Journal of Secondary Metabolite, 7(3), 174-180.
  • Apoorva, N., Rashmi, R. R., Preethi, J. S., Sindhu, H., & Teerthanath, S. (2020). Salvia hispanica (Chia) seeds afford hepatoprotection against Isoniazid and Rifampicin induced toxicity in a murine model. Research Journal of Pharmacy and Technology, 13(10), 4805-4810.
  • Rubavathi, S., Ayyappadasan, G., Sangeetha, N., Harini, T., Saranya, D., & Harshapradha, P. (2020). Studies on Antioxidant and Anti-obesity Activity of Salvia hispanica (Chia) Seeds Extracts. Journal of Drug Delivery and Therapeutics, 10(3-s), 98-106.
  • Schreyer, S., Klein, C., Pfeffer, A., Rasińska, J., Stahn, L., Knuth, K., . . . Koch, S. (2020). Chia seeds as a potential cognitive booster in the APP23 Alzheimer’s disease model. Scientific Reports, 10(1), 1-16.
  • Ayerza, R., & Coates, W. (2005). Ground chia seed and chia oil effects on plasma lipids and fatty acids in the rat. Nutrition Research, 25(11), 995-1003.
  • de Souza Ferreira, C., de Sousa Fomes, L. d. F., Santo da Silva, G. E., & Rosa, G. (2015). Effect of chia seed (Salvia hispanica L.) consumption on cardiovascular risk factors in humans: a systematic review. Nutricion Hospitalaria, 32(5), 1909-1918.
  • Jin, F., Nieman, D. C., Sha, W., Xie, G., Qiu, Y., & Jia, W. (2012). Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. Plant Foods for Human Nutrition, 67(2), 105-110.
  • Kačmárová, K., Lavová, B., Socha, P., & Urminská, D. (2016). Characterization of protein fractions and antioxidant activity of Chia seeds (Salvia Hispanica L.). Potravinarstvo Slovak Journal of Food Sciences, 10(1), 78-82.
  • Kulczyński, B., Kobus-Cisowska, J., Taczanowski, M., Kmiecik, D., & Gramza-Michałowska, A. (2019). The chemical composition and nutritional value of chia seeds—Current state of knowledge. Nutrients, 11(6), 1242.
  • Reyes-Caudillo, E., Tecante, A., & Valdivia-López, M. (2008). Dietary fibre content and antioxidant activity of phenolic compounds present in Mexican chia (Salvia hispanica L.) seeds. Food chemistry, 107(2), 656-663.
  • Ayerza, R. (2013). Seed composition of two chia (Salvia hispanica L.) genotypes which differ in seed color. Emirates Journal of Food & Agriculture (EJFA), 25(7).
  • Kähkönen, M. P., Hopia, A. I., Vuorela, H. J., Rauha, J.-P., Pihlaja, K., Kujala, T. S., & Heinonen, M. (1999). Antioxidant activity of plant extracts containing phenolic compounds. Journal of agricultural and food chemistry, 47(10), 3954-3962.
  • Sharma, O. P., & Bhat, T. K. (2009). DPPH antioxidant assay revisited. Food chemistry, 113(4), 1202-1205.
  • van den Berg, R., Haenen, G. R., van den Berg, H., & Bast, A. (1999). Applicability of an improved Trolox equivalent antioxidant capacity (TEAC) assay for evaluation of antioxidant capacity measurements of mixtures. Food chemistry, 66(4), 511-517.
  • Apak, R., Güçlü, K., Demirata, B., Özyürek, M., Çelik, S. E., Bektaşoğlu, B., Özyurt, D. (2007). Comparative evaluation of various total antioxidant capacity assays applied to phenolic compounds with the CUPRAC assay. Molecules, 12(7), 1496-1547.
  • Dudonne, S., Vitrac, X., Coutiere, P., Woillez, M., & Mérillon, J.-M. (2009). Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC assays. Journal of agricultural and food chemistry, 57(5), 1768-1774.
  • Yur, S., Tekin, M., Göger, F., Başer, K. H., Özek, T., & Özek, G. (2017). Composition and potential of Tanacetum haussknechtii Bornm. Grierson as antioxidant and inhibitor of acetylcholinesterase, tyrosinase, and α-amylase enzymes. International journal of food properties, 20(sup3), S2359-S2378.
  • Singleton, V. L., Orthofer, R., & Lamuela-Raventós, R. M. (1999). [14] Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent. Methods in enzymology, 299, 152-178.
  • Akkol, E. K., Göger, F., Koşar, M., & Başer, K. H. C. (2008). Phenolic composition and biological activities of Salvia halophila and Salvia virgata from Turkey. Food chemistry, 108(3), 942-949.
  • Miliauskas, G., Venskutonis, P., & Van Beek, T. (2004). Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food chemistry, 85(2), 231-237.
  • Knez Hrnčič, M., Ivanovski, M., Cör, D., & Knez, Ž. (2020). Chia Seeds (Salvia hispanica L.): an overview—phytochemical profile, isolation methods, and application. Molecules, 25(1), 11.
  • Coelho, M. S., & Salas-Mellado, M. d. l. M. (2014). Chemical characterization of chia (Salvia hispanica L.) for use in food products. Journal of Food and Nutrition Research, 2(5), 263-269.
  • Pellegrini, M., Lucas-Gonzalez, R., Sayas-Barberá, E., Fernández-López, J., Pérez-Álvarez, J. A., & Viuda-Martos, M. (2018). Bioaccessibility of phenolic compounds and antioxidant capacity of chia (Salvia hispanica L.) seeds. Plant foods for human nutrition, 73(1), 47-53.
  • de Falco, B., Fiore, A., Bochicchio, R., Amato, M., & Lanzotti, V. (2018). Metabolomic analysis by UAE-GC MS and antioxidant activity of Salvia hispanica (L.) seeds grown under different irrigation regimes. Industrial Crops and Products, 112, 584-592.

SİYAH VE BEYAZ CHIA TOHUMLARININ FARKLI YÖNTEMLERLE ELDE EDİLEN EKSTRELERİNİN BİYOLOJİK AKTİVİTE TAYİNİ

Yıl 2022, Cilt: 46 Sayı: 2, 277 - 290, 29.05.2022

Yasin Darı Süleyman Yur Gülmira Özek Ülkü Dilek Uysal Temel Özek

https://doi.org/10.33483/jfpau.971725

Öz

Amaç: Siyah ve beyaz chia tohumlarının biyolojik aktivitelerinin farklı esktraksiyon teknikleriyle elde edilen ekstrelerde tayinlerinin yapılması ve karşılaştırılması.
Gereç ve Yöntem: Farklı tekniklerle elde edilen ekstrelerin biyolojik aktivite çalışmaları, DPPH radikali süpürme potansiyeli testi, TEAC testi ve ORAC testi uygulanarak tayin edilmiştir. Ayrıca metanollü ekstre numunelerinde toplam fenol ve flavonoit miktar tayinleri yapılmıştır.
Sonuç ve Tartışma: Bu çalışmada fenol miktarı siyah chia tohumu için 9,86 mg GAE/g, beyaz chia tohumu için ise 12,69 mg GAE/g olarak belirlenmiş olup, toplam flavonoid miktarı ise siyah chia tohumu için 0,098 mg RE/mL ve beyaz chia tohumu için 0,099 mg RE/mL olarak belirlenmiştir. Ayrıca yapılan antioksidan aktivite testleri göz önüne alındığında, TEAC testi için en yüksek antioksidan aktivite, soğuk sıkım yöntemiyle elde edilen hem siyah hem de beyaz tohum ekstresinde, DPPH için en yüksek aktivite, soğuk sıkım tekniğiyle elde edilen beyaz tohum ekstresinde, ORAC testi için en yüksek aktivite ise Folch tekniğiyle elde edilen beyaz tohum ekstresinde görülmüştür.

Anahtar Kelimeler

Biyolojik aktivite chia DPPH ORAC TEAC

Proje Numarası

Project No: 19ADP063

Kaynakça

  • Bochicchio, R., Philips, T. D., Lovelli, S., Labella, R., Galgano, F., Di Marisco, A., . . . Amato, M. (2015). Innovative crop productions for healthy food: the case of chia (Salvia hispanica L.). The sustainability of agro-food and natural resource systems in the Mediterranean basin, 29-45.
  • Hernandez, L. M. (2012). Mucilage from chia seeds (Salvia hispanica): Microestructure, physico-chemical characterization and applications in food industry. Pontificia Universidad Catolica De Chile.
  • Delamare, A. P. L., Moschen-Pistorello, I. T., Artico, L., Atti-Serafini, L., & Echeverrigaray, S. (2007). Antibacterial activity of the essential oils of Salvia officinalis L. and Salvia triloba L. cultivated in South Brazil. Food chemistry, 100(2), 603-608.
  • Kowaleski, J., Quast, L. B., Steffens, J., Lovato, F., dos Santos, L. R., da Silva, S. Z., . Felicetti, M. A. (2020). Functional yogurt with strawberries and chia seeds. Food Bioscience, 37, 100726.
  • Wang, D. H., Wang, Z., Chen, R., Kothapalli, K., & Brenna, J. T. (2020). Very Long-Chain Branched-Chain Fatty Acids in Chia Seeds: Implications for Human Use. Journal of Agricultural and Food Chemistry, 68(47), 13871-13878.
  • del Carmen Beltran-Orozco, M., Martinez-Olguin, A., & del Carmen Robles-Ramirez, M. (2020). Changes in the nutritional composition and antioxidant capacity of chia seeds (Salvia hispanica L.) during germination process. Food Science and Biotechnology, 29(6), 751-757.
  • Mihafu, F. D., Kiage, B. N., Okoth, J. K., & Nyerere, A. K. (2020). Nutritional Composition and Qualitative Phytochemical Analysis of Chia Seeds (Salvia hispanica L.) Grown in East Africa. Current Nutrition and Food Science, 16(6), 988-995.
  • Mihafu, F. D., Kiage, B. N., Kimang’a, A. N., & Okoth, J. K. (2020). Effect of chia seeds (Salvia hispanica) on postprandial glycaemia, body weight and hematological parameters in rats fed a high fat and fructose diet. International Journal of Biological and Chemical Sciences, 14(5), 1752-1762.
  • Güzel, S., Ülger, M., & Yusuf, Ö. (2020). Antimicrobial and Antiproliferative Activities of Chia (Salvia hispanica L.) Seeds. International Journal of Secondary Metabolite, 7(3), 174-180.
  • Apoorva, N., Rashmi, R. R., Preethi, J. S., Sindhu, H., & Teerthanath, S. (2020). Salvia hispanica (Chia) seeds afford hepatoprotection against Isoniazid and Rifampicin induced toxicity in a murine model. Research Journal of Pharmacy and Technology, 13(10), 4805-4810.
  • Rubavathi, S., Ayyappadasan, G., Sangeetha, N., Harini, T., Saranya, D., & Harshapradha, P. (2020). Studies on Antioxidant and Anti-obesity Activity of Salvia hispanica (Chia) Seeds Extracts. Journal of Drug Delivery and Therapeutics, 10(3-s), 98-106.
  • Schreyer, S., Klein, C., Pfeffer, A., Rasińska, J., Stahn, L., Knuth, K., . . . Koch, S. (2020). Chia seeds as a potential cognitive booster in the APP23 Alzheimer’s disease model. Scientific Reports, 10(1), 1-16.
  • Ayerza, R., & Coates, W. (2005). Ground chia seed and chia oil effects on plasma lipids and fatty acids in the rat. Nutrition Research, 25(11), 995-1003.
  • de Souza Ferreira, C., de Sousa Fomes, L. d. F., Santo da Silva, G. E., & Rosa, G. (2015). Effect of chia seed (Salvia hispanica L.) consumption on cardiovascular risk factors in humans: a systematic review. Nutricion Hospitalaria, 32(5), 1909-1918.
  • Jin, F., Nieman, D. C., Sha, W., Xie, G., Qiu, Y., & Jia, W. (2012). Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. Plant Foods for Human Nutrition, 67(2), 105-110.
  • Kačmárová, K., Lavová, B., Socha, P., & Urminská, D. (2016). Characterization of protein fractions and antioxidant activity of Chia seeds (Salvia Hispanica L.). Potravinarstvo Slovak Journal of Food Sciences, 10(1), 78-82.
  • Kulczyński, B., Kobus-Cisowska, J., Taczanowski, M., Kmiecik, D., & Gramza-Michałowska, A. (2019). The chemical composition and nutritional value of chia seeds—Current state of knowledge. Nutrients, 11(6), 1242.
  • Reyes-Caudillo, E., Tecante, A., & Valdivia-López, M. (2008). Dietary fibre content and antioxidant activity of phenolic compounds present in Mexican chia (Salvia hispanica L.) seeds. Food chemistry, 107(2), 656-663.
  • Ayerza, R. (2013). Seed composition of two chia (Salvia hispanica L.) genotypes which differ in seed color. Emirates Journal of Food & Agriculture (EJFA), 25(7).
  • Kähkönen, M. P., Hopia, A. I., Vuorela, H. J., Rauha, J.-P., Pihlaja, K., Kujala, T. S., & Heinonen, M. (1999). Antioxidant activity of plant extracts containing phenolic compounds. Journal of agricultural and food chemistry, 47(10), 3954-3962.
  • Sharma, O. P., & Bhat, T. K. (2009). DPPH antioxidant assay revisited. Food chemistry, 113(4), 1202-1205.
  • van den Berg, R., Haenen, G. R., van den Berg, H., & Bast, A. (1999). Applicability of an improved Trolox equivalent antioxidant capacity (TEAC) assay for evaluation of antioxidant capacity measurements of mixtures. Food chemistry, 66(4), 511-517.
  • Apak, R., Güçlü, K., Demirata, B., Özyürek, M., Çelik, S. E., Bektaşoğlu, B., Özyurt, D. (2007). Comparative evaluation of various total antioxidant capacity assays applied to phenolic compounds with the CUPRAC assay. Molecules, 12(7), 1496-1547.
  • Dudonne, S., Vitrac, X., Coutiere, P., Woillez, M., & Mérillon, J.-M. (2009). Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC assays. Journal of agricultural and food chemistry, 57(5), 1768-1774.
  • Yur, S., Tekin, M., Göger, F., Başer, K. H., Özek, T., & Özek, G. (2017). Composition and potential of Tanacetum haussknechtii Bornm. Grierson as antioxidant and inhibitor of acetylcholinesterase, tyrosinase, and α-amylase enzymes. International journal of food properties, 20(sup3), S2359-S2378.
  • Singleton, V. L., Orthofer, R., & Lamuela-Raventós, R. M. (1999). [14] Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent. Methods in enzymology, 299, 152-178.
  • Akkol, E. K., Göger, F., Koşar, M., & Başer, K. H. C. (2008). Phenolic composition and biological activities of Salvia halophila and Salvia virgata from Turkey. Food chemistry, 108(3), 942-949.
  • Miliauskas, G., Venskutonis, P., & Van Beek, T. (2004). Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food chemistry, 85(2), 231-237.
  • Knez Hrnčič, M., Ivanovski, M., Cör, D., & Knez, Ž. (2020). Chia Seeds (Salvia hispanica L.): an overview—phytochemical profile, isolation methods, and application. Molecules, 25(1), 11.
  • Coelho, M. S., & Salas-Mellado, M. d. l. M. (2014). Chemical characterization of chia (Salvia hispanica L.) for use in food products. Journal of Food and Nutrition Research, 2(5), 263-269.
  • Pellegrini, M., Lucas-Gonzalez, R., Sayas-Barberá, E., Fernández-López, J., Pérez-Álvarez, J. A., & Viuda-Martos, M. (2018). Bioaccessibility of phenolic compounds and antioxidant capacity of chia (Salvia hispanica L.) seeds. Plant foods for human nutrition, 73(1), 47-53.
  • de Falco, B., Fiore, A., Bochicchio, R., Amato, M., & Lanzotti, V. (2018). Metabolomic analysis by UAE-GC MS and antioxidant activity of Salvia hispanica (L.) seeds grown under different irrigation regimes. Industrial Crops and Products, 112, 584-592.
Toplam 32 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri
Bölüm Araştırma Makalesi
Yazarlar

Yasin Darı Bu kişi benim 0000-0003-2948-2923

Süleyman Yur Bu kişi benim 0000-0001-5980-4992

Gülmira Özek 0000-0001-8908-6098

Ülkü Dilek Uysal 0000-0003-1572-9753

Temel Özek 0000-0003-4251-8783

Proje Numarası Project No: 19ADP063
Yayımlanma Tarihi 29 Mayıs 2022
Gönderilme Tarihi 16 Temmuz 2021
Kabul Tarihi 10 Ocak 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 46 Sayı: 2

Kaynak Göster

APA Darı, Y., Yur, S., Özek, G., Uysal, Ü. D., vd. (2022). BIOLOGICAL ACTIVITY DETERMINATION OF BLACK AND WHITE CHIA SEED EXTRACTS OBTAINED BY DIFFERENT EXTRACTION METHODS. Journal of Faculty of Pharmacy of Ankara University, 46(2), 277-290. https://doi.org/10.33483/jfpau.971725
AMA Darı Y, Yur S, Özek G, Uysal ÜD, Özek T. BIOLOGICAL ACTIVITY DETERMINATION OF BLACK AND WHITE CHIA SEED EXTRACTS OBTAINED BY DIFFERENT EXTRACTION METHODS. Ankara Ecz. Fak. Derg. Mayıs 2022;46(2):277-290. doi:10.33483/jfpau.971725
Chicago Darı, Yasin, Süleyman Yur, Gülmira Özek, Ülkü Dilek Uysal, ve Temel Özek. “BIOLOGICAL ACTIVITY DETERMINATION OF BLACK AND WHITE CHIA SEED EXTRACTS OBTAINED BY DIFFERENT EXTRACTION METHODS”. Journal of Faculty of Pharmacy of Ankara University 46, sy. 2 (Mayıs 2022): 277-90. https://doi.org/10.33483/jfpau.971725.
EndNote Darı Y, Yur S, Özek G, Uysal ÜD, Özek T (01 Mayıs 2022) BIOLOGICAL ACTIVITY DETERMINATION OF BLACK AND WHITE CHIA SEED EXTRACTS OBTAINED BY DIFFERENT EXTRACTION METHODS. Journal of Faculty of Pharmacy of Ankara University 46 2 277–290.
IEEE Y. Darı, S. Yur, G. Özek, Ü. D. Uysal, ve T. Özek, “BIOLOGICAL ACTIVITY DETERMINATION OF BLACK AND WHITE CHIA SEED EXTRACTS OBTAINED BY DIFFERENT EXTRACTION METHODS”, Ankara Ecz. Fak. Derg., c. 46, sy. 2, ss. 277–290, 2022, doi: 10.33483/jfpau.971725.
ISNAD Darı, Yasin vd. “BIOLOGICAL ACTIVITY DETERMINATION OF BLACK AND WHITE CHIA SEED EXTRACTS OBTAINED BY DIFFERENT EXTRACTION METHODS”. Journal of Faculty of Pharmacy of Ankara University 46/2 (Mayıs 2022), 277-290. https://doi.org/10.33483/jfpau.971725.
JAMA Darı Y, Yur S, Özek G, Uysal ÜD, Özek T. BIOLOGICAL ACTIVITY DETERMINATION OF BLACK AND WHITE CHIA SEED EXTRACTS OBTAINED BY DIFFERENT EXTRACTION METHODS. Ankara Ecz. Fak. Derg. 2022;46:277–290.
MLA Darı, Yasin vd. “BIOLOGICAL ACTIVITY DETERMINATION OF BLACK AND WHITE CHIA SEED EXTRACTS OBTAINED BY DIFFERENT EXTRACTION METHODS”. Journal of Faculty of Pharmacy of Ankara University, c. 46, sy. 2, 2022, ss. 277-90, doi:10.33483/jfpau.971725.
Vancouver Darı Y, Yur S, Özek G, Uysal ÜD, Özek T. BIOLOGICAL ACTIVITY DETERMINATION OF BLACK AND WHITE CHIA SEED EXTRACTS OBTAINED BY DIFFERENT EXTRACTION METHODS. Ankara Ecz. Fak. Derg. 2022;46(2):277-90.
 Kapak Resmi İndir

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.