Öz
Soft tissue expanders, which have many uses in biomedical applications, are also encountered in surgical applications. Soft tissue expanders play an important role in ensuring osseointegration of dental implants. In this study, natural polymers chitosan (CS), hyaluronic acid (HA) and gelatin (GEL) were used. Synthesis of CS, CS-HA, CS-GEL, GEL-HA and CS-HA-GEL hydrogels has been performed. Gamma radiation was used in hydrogel synthesis with HAP. They were characterized by Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). Dynamic swelling tests were performed in distilled water. Swelling behavior and swelling kinetics of hydrogels were determined. The effect of cross-linker concentration and different cross-linkers (glutaraldehyde (GA) and hydroxyapatite (HAP)) on swelling behavior was evaluated. Fickian mechanism has been observed in the diffusion of hydrogels. The results show that the hydrophilic CS-HA-1 hydrogel with the highest mass swelling and the most suitable swelling profile can be used as a soft tissue expander in biomedical applications.
Anahtar Kelimeler
Hydrogel Natural polymers Soft tissue expansion Tissue expander
Kaynakça
- Caló, E. ve Khutoryanskiy, V.V., "Biomedical Applications of Hydrogels: A Review of Patents and Commercial Products", European polymer journal, 65., 252-267, 2015.
- Zohouriaan-Mehr, M. ve Kabiri, K., "Superabsorbent Polymer Materials: A Review", Iranian polymer journal, 17(6)., 451-447, 2008.
- Yang, J.M., Olanrele, O.S., Zhang, X., Hsu, C.C., "Fabrication of Hydrogel Materials for Biomedical Applications", Advances in experimental medicine and biology, 1077., 197–224, 2018.
- Küçükkurt, S. ve Alpaslan, G., "Yumuşak Doku Genişletici Materyaller ve Oral & Maksillofasiyal Cerrahide Kullanımları", Atatürk üniversitesi diş hekimliği fakültesi dergisi, 26(4)., 0-0, 2016.
- Wiese, K.G., "Osmotically Induced Tissue Expansion with Hydrogels: A New Dimension in Tissue Expansion? A Preliminary Report", Journal of cranio-maxillo-facial surgery: official publication of the european association for cranio-maxillo-facial surgery, 21(7)., 309–313, 1993.
- Pikos, M.A., "Block Autografts for Localized Ridge Augmentation: Part II. The Posterior Mandible", Implant dentistry, 9(1)., 67–75, 2000.
- Kaner, D. ve Friedmann, A., "Soft Tissue Expansion with Self-Filling Osmotic Tissue Expanders Before Vertical Ridge Aaugmentation: A Proof of Principle Study", Journal of clinical periodontology, 38(1)., 95–101, 2011.
- Von See, C., Gellrich, N.C., Jachmann, U., Laschke, M.W., Bormann, K.H., Rücker, M., "Bone Augmentation After Soft-Tissue Expansion Using Hydrogel Expanders: Effects on Microcirculation and Osseointegration", Clinical oral implants research, 21(8)., 842–847, 2010.
- Neumann, C.G., "The Expansion of An Area of Skin by Progressive Distention of A Subcutaneous Balloon; Use of the Method for Securing Skin for Subtotal Reconstruction of the Ear", Plastic and reconstructive surgery (1946), 19(2)., 124–130, 1957.
- Austad, E.D. ve Rose, G.L., "A Self-Inflating Tissue Expander", Plastic and reconstructive surgery, 70(5)., 588–594, 1982.
- Downes, R., Lavin, M., Collin, R., "Hydrophilic Expanders for the Congenital Anophthalmic Socket", Advances in ophthalmic plastic and reconstructive surgery, 9., 57–61, 1992.
- Zeiter, D.J., Ries, W.L., Weir, T.L., Mishkin, D.J., Sanders, J.J., "The Use of A Soft Tissue Expander in An Alveolar Bone Ridge Augmentation for Implant Placement", The international journal of periodontics & restorative dentistry, 18(4)., 403–409, 1998.
- Miranda, D.G., Malmonge, S.M., Campos, D.M., Attik, N.G., Grosgogeat, B., Gritsch, K., "A Chitosan-Hyaluronic Acid Hydrogel Scaffold for Periodontal Tissue Engineering", Journal of biomedical materials research, part B: applied biomaterials, 104(8)., 1691–1702, 2016.
- Ahmadian, E., Eftekhari, A., Dizaj, S.M., Sharifi, S., Mokhtarpour, M., Nasibova, A.N., Khalilov, R., Samiei, M., "The Effect of Hyaluronic Acid Hydrogels on Dental Pulp Stem Cells Behavior", International journal of biological macromolecules, 140., 245–254, 2019.
- Taşdelen, B., Erdoğan, S., Bekar, B., "Radiation Synthesis and Characterization of Chitosan/Hyraluronic Acid/Hydroxyapatite Hydrogels: Drug Uptake and Drug Delivery Systems", Materials today: proceedings, 5(8)., 15990–15997, 2018.
- Gonçalves, V.L., Laranjeira, M.C.M., Fávere, V.T., Pedrosa, R.C., "Effect of Crosslinking Agents on Chitosan Microspheres in Controlled Release of Diclofenac Sodium", Polímeros: ciência e tecnologia, 15(1)., 6-12, 2005.
- Kathuria, N., Tripathi, A., Kar, K.K., Kumar, A., "Synthesis and Characterization of Elastic and Macroporous Chitosan-Gelatin Cryogels for Tissue Engineering", Acta biomaterialia, 5(1)., 406–418, 2009.
- Peniche, C., Cohen, M.E., Vazquez, B., Roman, J.S., "Water Sorption of Flexible Networks Based on 2-Hydroxyethyl Methacrylate-Triethylenglycol Dimethacrylate Copolymers", Polymer, 38(24)., 5977-5982, 1997.
- Azizian S., "Kinetic Models of Sorption: A Theoretical Analysis", Journal of colloid and interface science, 276(1)., 47–52, 2004.
- Peppas, N.A. ve Franson, N.M., "The Swelling Interface Number As A Criterion for Prediction of Diffusional Solute Release Mechanisms in Swellable Polymers", Journal of polymer science: polymer physics edition, 21(6)., 983–997, 1983.
- Dengre, R., Bajpai, M., Bajpai, S.K., "Release of Vitamin B12 from poly(N-vinyl-2-pyrrolidone)-Crosslinked Polyacrylamide Hydrogels: A Kinetic Study", Journal of applied polymer science, 76., 1706-1714, 2000.
- Drury, J.L., ve Mooney, D.J., "Hydrogels for Tissue Engineering: Scaffold Design Variables and Applications", Biomaterials, 24(24)., 4337–4351, 2003.
- Lv, B., Bu, X., Da, Y., Duan, P., Wang, H., Ren, J., Ma, J., "Gelatin/PAM Double Network Hydrogels with Super-Compressibility", Polymer, 210(23)., 123021, 2020.
- Zhang, F., He, C., Cao, L., Feng, W., Wang, H., Mo, X., Wang, J., "Fabrication of Gelatin-Hyaluronic Acid Hybrid Scaffolds with Tunable Porous Structures for Soft Tissue Engineering", International journal of biological macromolecules, 48(3)., 474–481, 2011.
- Bazmandeh, A.Z., Mirzaei, E., Fadaie, M., Shirian, S., Ghasemi, Y., "Dual Spinneret Electrospun Nanofibrous/Gel Structure of Chitosan-Gelatin/Chitosan-Hyaluronic Acid As A Wound Dressing: In-vitro and In-vivo Studies", International journal of biological macromolecules, 162., 359–373, 2020.
- Tomihata, K. ve Ikada, Y., "Crosslinking of Hyaluronic Acid with Glutaraldehyde", Journal of polymer science, part A: polymer chemistry, 35(16)., 3553-3559, 1997.
- Ganji, F., Vasheghani-Farahani, S., Vasheghani-Farahani, E., "Theoretical Description of Hydrogel Swelling: A Review", Iranian polymer journal, 19(5)., 375-398, 2010.
- Doğu, Y. ve Okay, O., "Swelling-Deswelling Kinetics of poly(N-isopropylacrylamide) Hydrogels Formed in PEG Solutions", Journal of applied polymer science, 99(1)., 37–44, 2006
Öz
Biyomedikal uygulamalarda pek çok kullanımı bulunan yumuşak doku genişleticiler cerrahi uygulamalarda karşımıza çıkmaktadır. Dental implantların osseointegrasyonunun sağlanmasında yumuşak doku genişleticiler önemli bir rol oynamaktadır. Bu çalışmada, kitosan (CS), hyaluronik asit (HA) ve jelatin (GEL) doğal polimerleri kullanılmıştır. CS, CS-HA, CS-GEL, GEL-HA ve CS-HA-GEL hidrojellerinin sentezi gerçekleştirilmiştir. HAP ile hidrojel sentezinde gama radyasyon kullanılmıştır. Fourier Dönüşümlü Kızılötesi Spektroskopisi (FTIR) ve Taramalı Elektron Mikroskobu (SEM) ile karakterizasyonları yapılmıştır. Dinamik şişme testleri distile suda gerçekleştirilmiştir. Hidrojellerin şişme davranışları ve şişme kinetikleri belirlenmiştir. Çapraz bağlayıcı konsantrasyonunun ve farklı çapraz bağlayıcıların (glutaraldehit (GA) ve hidroksiapatit (HAP)) şişme davranışına etkisi değerlendirilmiştir. Hidrojellerin difüzyonunda Fickian mekanizması görülmüştür. Sonuçlar, en yüksek kütlece şişmeye ve en uygun şişme profiline sahip hidrofilik yapılı CS-HA-1 hidrojelinin biyomedikal uygulamalarda yumuşak doku genişletici olarak kullanılabileceği göstermektedir..
Anahtar Kelimeler
Doğal polimerler Doku genişletici Hidrojel Yumuşak doku genişlemesi
Kaynakça
- Caló, E. ve Khutoryanskiy, V.V., "Biomedical Applications of Hydrogels: A Review of Patents and Commercial Products", European polymer journal, 65., 252-267, 2015.
- Zohouriaan-Mehr, M. ve Kabiri, K., "Superabsorbent Polymer Materials: A Review", Iranian polymer journal, 17(6)., 451-447, 2008.
- Yang, J.M., Olanrele, O.S., Zhang, X., Hsu, C.C., "Fabrication of Hydrogel Materials for Biomedical Applications", Advances in experimental medicine and biology, 1077., 197–224, 2018.
- Küçükkurt, S. ve Alpaslan, G., "Yumuşak Doku Genişletici Materyaller ve Oral & Maksillofasiyal Cerrahide Kullanımları", Atatürk üniversitesi diş hekimliği fakültesi dergisi, 26(4)., 0-0, 2016.
- Wiese, K.G., "Osmotically Induced Tissue Expansion with Hydrogels: A New Dimension in Tissue Expansion? A Preliminary Report", Journal of cranio-maxillo-facial surgery: official publication of the european association for cranio-maxillo-facial surgery, 21(7)., 309–313, 1993.
- Pikos, M.A., "Block Autografts for Localized Ridge Augmentation: Part II. The Posterior Mandible", Implant dentistry, 9(1)., 67–75, 2000.
- Kaner, D. ve Friedmann, A., "Soft Tissue Expansion with Self-Filling Osmotic Tissue Expanders Before Vertical Ridge Aaugmentation: A Proof of Principle Study", Journal of clinical periodontology, 38(1)., 95–101, 2011.
- Von See, C., Gellrich, N.C., Jachmann, U., Laschke, M.W., Bormann, K.H., Rücker, M., "Bone Augmentation After Soft-Tissue Expansion Using Hydrogel Expanders: Effects on Microcirculation and Osseointegration", Clinical oral implants research, 21(8)., 842–847, 2010.
- Neumann, C.G., "The Expansion of An Area of Skin by Progressive Distention of A Subcutaneous Balloon; Use of the Method for Securing Skin for Subtotal Reconstruction of the Ear", Plastic and reconstructive surgery (1946), 19(2)., 124–130, 1957.
- Austad, E.D. ve Rose, G.L., "A Self-Inflating Tissue Expander", Plastic and reconstructive surgery, 70(5)., 588–594, 1982.
- Downes, R., Lavin, M., Collin, R., "Hydrophilic Expanders for the Congenital Anophthalmic Socket", Advances in ophthalmic plastic and reconstructive surgery, 9., 57–61, 1992.
- Zeiter, D.J., Ries, W.L., Weir, T.L., Mishkin, D.J., Sanders, J.J., "The Use of A Soft Tissue Expander in An Alveolar Bone Ridge Augmentation for Implant Placement", The international journal of periodontics & restorative dentistry, 18(4)., 403–409, 1998.
- Miranda, D.G., Malmonge, S.M., Campos, D.M., Attik, N.G., Grosgogeat, B., Gritsch, K., "A Chitosan-Hyaluronic Acid Hydrogel Scaffold for Periodontal Tissue Engineering", Journal of biomedical materials research, part B: applied biomaterials, 104(8)., 1691–1702, 2016.
- Ahmadian, E., Eftekhari, A., Dizaj, S.M., Sharifi, S., Mokhtarpour, M., Nasibova, A.N., Khalilov, R., Samiei, M., "The Effect of Hyaluronic Acid Hydrogels on Dental Pulp Stem Cells Behavior", International journal of biological macromolecules, 140., 245–254, 2019.
- Taşdelen, B., Erdoğan, S., Bekar, B., "Radiation Synthesis and Characterization of Chitosan/Hyraluronic Acid/Hydroxyapatite Hydrogels: Drug Uptake and Drug Delivery Systems", Materials today: proceedings, 5(8)., 15990–15997, 2018.
- Gonçalves, V.L., Laranjeira, M.C.M., Fávere, V.T., Pedrosa, R.C., "Effect of Crosslinking Agents on Chitosan Microspheres in Controlled Release of Diclofenac Sodium", Polímeros: ciência e tecnologia, 15(1)., 6-12, 2005.
- Kathuria, N., Tripathi, A., Kar, K.K., Kumar, A., "Synthesis and Characterization of Elastic and Macroporous Chitosan-Gelatin Cryogels for Tissue Engineering", Acta biomaterialia, 5(1)., 406–418, 2009.
- Peniche, C., Cohen, M.E., Vazquez, B., Roman, J.S., "Water Sorption of Flexible Networks Based on 2-Hydroxyethyl Methacrylate-Triethylenglycol Dimethacrylate Copolymers", Polymer, 38(24)., 5977-5982, 1997.
- Azizian S., "Kinetic Models of Sorption: A Theoretical Analysis", Journal of colloid and interface science, 276(1)., 47–52, 2004.
- Peppas, N.A. ve Franson, N.M., "The Swelling Interface Number As A Criterion for Prediction of Diffusional Solute Release Mechanisms in Swellable Polymers", Journal of polymer science: polymer physics edition, 21(6)., 983–997, 1983.
- Dengre, R., Bajpai, M., Bajpai, S.K., "Release of Vitamin B12 from poly(N-vinyl-2-pyrrolidone)-Crosslinked Polyacrylamide Hydrogels: A Kinetic Study", Journal of applied polymer science, 76., 1706-1714, 2000.
- Drury, J.L., ve Mooney, D.J., "Hydrogels for Tissue Engineering: Scaffold Design Variables and Applications", Biomaterials, 24(24)., 4337–4351, 2003.
- Lv, B., Bu, X., Da, Y., Duan, P., Wang, H., Ren, J., Ma, J., "Gelatin/PAM Double Network Hydrogels with Super-Compressibility", Polymer, 210(23)., 123021, 2020.
- Zhang, F., He, C., Cao, L., Feng, W., Wang, H., Mo, X., Wang, J., "Fabrication of Gelatin-Hyaluronic Acid Hybrid Scaffolds with Tunable Porous Structures for Soft Tissue Engineering", International journal of biological macromolecules, 48(3)., 474–481, 2011.
- Bazmandeh, A.Z., Mirzaei, E., Fadaie, M., Shirian, S., Ghasemi, Y., "Dual Spinneret Electrospun Nanofibrous/Gel Structure of Chitosan-Gelatin/Chitosan-Hyaluronic Acid As A Wound Dressing: In-vitro and In-vivo Studies", International journal of biological macromolecules, 162., 359–373, 2020.
- Tomihata, K. ve Ikada, Y., "Crosslinking of Hyaluronic Acid with Glutaraldehyde", Journal of polymer science, part A: polymer chemistry, 35(16)., 3553-3559, 1997.
- Ganji, F., Vasheghani-Farahani, S., Vasheghani-Farahani, E., "Theoretical Description of Hydrogel Swelling: A Review", Iranian polymer journal, 19(5)., 375-398, 2010.
- Doğu, Y. ve Okay, O., "Swelling-Deswelling Kinetics of poly(N-isopropylacrylamide) Hydrogels Formed in PEG Solutions", Journal of applied polymer science, 99(1)., 37–44, 2006
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Biyomateryaller |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Erken Görünüm Tarihi | 31 Aralık 2023 |
| Yayımlanma Tarihi | 31 Aralık 2023 |
| Gönderilme Tarihi | 13 Kasım 2023 |
| Kabul Tarihi | 21 Aralık 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 6 Sayı: 2 |
