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Prophylactic and Therapeutic Probiotic Use in Children

Yıl 2024, Cilt: 8 Sayı: 1, 32 - 43, 30.04.2024
https://doi.org/10.34084/bshr.1465778

Öz

Probiotics are live microorganisms that provide health benefits when administered in adequate amounts. By adhering to the intestinal epithelium and mucus, probiotics compete with pathogens, reducing pathogen invasion, and produce antimicrobial substances such as bacteriocins, hydrogen peroxide, and organic acids, thereby exerting antimicrobial effects. Due to these effects, the use of probiotics has been a subject of research for the prevention and treatment of gastrointestinal diseases for many years. The systemic effects of probiotics, such as inducing the production of regulatory T cells and redirecting the response to allergens towards the Th1 direction, have provided hope for their use in allergic diseases. In recent years, research has been conducted on many diseases in which probiotics are used for prophylactic or therapeutic purposes. From these studies, important evidence has been obtained showing that the effectiveness of probiotics is specific to the strain and the disease. The purpose of this article is to review the disease-specific use of probiotics in the light of current literature.

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Kaynakça

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Çocuklarda Profilaktik ve Terapötik Probiyotik Kullanımı

Yıl 2024, Cilt: 8 Sayı: 1, 32 - 43, 30.04.2024
https://doi.org/10.34084/bshr.1465778

Öz

Probiyotikler uygun miktarda uygulandıklarında kişiye sağlık açısından fayda sağlayan canlı mikroorganizmalardır. Probiyotikler bağırsak epiteli ve mukusuna yapışma yetenekleri sayesinde patojenlerle yarışarak patojen istilasını azaltırlar, bakteriyosin, hidrojen peroksit ve organik asitler gibi antimikrobiyal ürünler üretip antimikrobiyal etki sağlarlar. Bu etkileri sayesinde probiyotiklerin özellikle gastrointestinal sistem hastalıklarının önlenmesi ve tedavisinde kullanımı uzun yıllardır araştırma konusu olmuştur. Probiyotiklerin regülatör T hücre üretiminin indüklenmesi, alerjenlere cevabın Th1 yönüne saptırılması gibi sistemik etkileri olması alerjik hastalıklarda kullanımı için umut olmuştur. Son yıllarda probiyotiklerin profilaktik veya tedavi amaçlı kullanıldığı pek çok hastalıkla ilgili araştırmalar yapılmaktadır. Bu çalışmalardan probiyotiklerin etkinliğinin suş ve hastalık açısından özel olduğunu gösteren önemli kanıtlar elde edilmiştir. Bu yazının amacı probiyotiklerin hastalık tipine bağlı kullanımını güncel bilgiler ışığında gözden geçirmektir.

Proje Numarası

Yok

Kaynakça

  • 1. Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014; 11(8):506-14.
  • Coşkun T. Pro-, Pre- ve Sinbiyotikler. Çocuk Sağlığı ve Hastalıkları Dergisi 2006;49: 128-148.
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  • Garofoli F, Civardi E, Indrio F, Mazzucchelli I, Angelini M, Tinelli C, Stronati M. The early administration of Lactobacillus reuteri DSM 17938 controls regurgitation eisodes in full-term breastfed infants. Int J Food Sci Nutr. 2014; 65(5):646-8.
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  • Miele E, Pascarella F, Giannetti E, Quaglietta L, Baldassano RN, Staiano A. Effect of a probiotic preparation (VSL#3) on induction and maintenance of remission in children with ulcerative colitis. Am J Gastroenterol. 2009;104(2):437-43.
  • Oliva S, Di Nardo G, Ferrari F, Mallardo S, Rossi P, Patrizi G, Cucchiara S, Stronati L. Randomised Clinical Trial: The Effectiveness of Lactobacillus reuteri ATCC 55730 Rectal Enema in Children with Active Distal Ulcerative Colitis. Aliment. Pharmacol. Ther.2012; 35: 327–334.
  • Iheozor-Ejiofor Z, Kaur L, Gordon M, Baines PA, Sinopoulou V, Akobeng AK. Probiotics for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev. 2020;3(3):CD007443
  • Scarpato E, Russo M, Staiano A. Probiotics in Pediatric Gastroenterology. Emerging Indications in Inflammatory Bowel Diseases. J. Clin. Gastroenterol. 2018, 52, S7–S9.
  • Demirören K, Özen H. İnflamatuar Bağırsak Hastalıklarının Tedavisinde Probiyotikler. Turkiye Klinikleri J Pediatr Sci 2012;8:34-42.
  • Bousvaros A, Guandalini S, Baldassano RN, Botelho C, Evans J, Ferry GD, et al. A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn’s disease. Inflamm Bowel Dis 2005;11:833-9.
  • Li S, Huang XL, Sui JZ, Chen SY, Xie YT, Deng Y, Wang J, Xie L, Li TJ, He Y, Peng QL, Qin X, Zeng ZY. Meta-analysis of randomized controlled trials on the efficacy of probiotics in Helicobacter pylori eradication therapy in children. Eur J Pediatr. 2014;173(2):153-61.
  • Szajewska H, Horvath A, Kołodziej M. Systematic review with meta-analysis: Saccharomyces boulardii supplementation and eradication of Helicobacter pylori infection. Aliment Pharmacol Ther. 2015;41(12):1237-45.
  • Morrow AL, Lagomarcino AJ, Schibler KR, et al. Early microbial and metabolomic signatures predict later onset of necrotizing enterocolitis in preterm infants. Microbiome. 2013;1:13.
  • Van den Akker CHP, van Goudoever JB, Szajewska H, Embleton ND, Hojsak I, Reid D, Shamir R; ESPGHAN Working Group for Probiotics, Prebiotics & Committee on Nutrition. Probiotics for Preterm Infants: A Strain-Specific Systematic Review and Network Meta-analysis. J Pediatr Gastroenterol Nutr. 2018;67(1):103-122.
  • Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology. 2015;107(1):56-9.
  • Kunz AN, Noel JM, Fairchok MP. Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome. J Pediatr Gastroenterol Nutr. 2004; 38(4):457-8.
  • Chiang MC, Chen CL, Feng Y, Chen CC, Lien R, Chiu CH. Lactobacillus rhamnosus sepsis associated with probiotic therapy in an extremely preterm infant: Pathogenesis and a review for clinicians. J Microbiol Immunol Infect. 2021; 54(4):575-580.
  • Martinelli M, Banderali G, Bobbio M, Civardi E, Chiara A, D'Elios S, Lo Vecchio A, Olivero M, Peroni D, Romano C, Stronati M, Turra R, Viola I, Staiano A, Villani A. Correction to: Probiotics' efficacy in paediatric diseases: which is the evidence? A critical review on behalf of the Italian Society of Pediatrics. Ital J Pediatr. 2020; 46(1):116.
  • Adams M, Bassler D, Darlow BA, Lui K, Reichman B, Hakansson S, Norman M, Lee SK, Helenius KK, Lehtonen L, San Feliciano L, Vento M, Moroni M, Beltempo M, Yang J, Shah PS; International Network for EvaluatingOutcomes (iNeo) of Neonates. Preventive strategies and factors associated with surgically treated necrotising enterocolitis in extremely preterm infants: an international unit survey linked with retrospective cohort data analysis. BMJ Open. 2019;9(10):e031086.
  • van den Akker CHP, van Goudoever JB, Shamir R, Domellöf M, Embleton ND, Hojsak I, Lapillonne A, Mihatsch WA, Berni Canani R, Bronsky J, Campoy C, Fewtrell MS, Fidler Mis N, Guarino A, Hulst JM, Indrio F, Kolaček S, Orel R, Vandenplas Y, Weizman Z, Szajewska H. Probiotics and Preterm Infants: A Position Paper by the European Society for Paediatric Gastroenterology Hepatology and Nutrition Committee on Nutrition and the European Society for Paediatric Gastroenterology Hepatology and Nutrition Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr. 2020;70(5):664-680.
  • Galli E, Cinicola B, Carello R, Caimmi S, Brindisi G, De Castro G, Zicari AM, Tosca MA, Manti S, Martelli A, Calvani M, Cravidi C, Marseglia GL, Cardinale F, Miraglia Del Giudice M, Caffarelli C, Duse M. Atopic dermatitis. Acta Biomed. 2020; 91(11-S):e2020011.
  • Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine AD. Atopic dermatitis. Nat Rev Dis Primers. 2018;4(1):1.
  • Ng SC, Hart AL, Kamm MA, Stagg AJ, Knight SC. Mechanisms of action of probiotics: recent advances. Inflamm Bowel Dis 2009; 15: 300-310.
  • Fiocchi A, Pawankar R, Cuello-Garcia C, Ahn K, Al-Hammadi S, Agarwal A, Beyer K, Burks W, Canonica GW, Ebisawa M, Gandhi S, Kamenwa R, Lee BW, Li H, Prescott S, Riva JJ, Rosenwasser L, Sampson H, Spigler M, Terracciano L. et al. World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics. World Allergy Organ J. 2015;8(1):4.
  • Amalia N, Orchard D, Francis KL, King E. Systematic review and meta-analysis on the use of probiotic supplementation in pregnant mother, breastfeeding mother and infant for the prevention of atopic dermatitis in children. Australas J Dermatol. 2020;61(2):e158-e173.
  • Sun M, Luo J, Liu H, Xi Y, Lin Q. Can Mixed Strains of Lactobacillus and Bifidobacterium Reduce Eczema in Infants under Three Years of Age? A Meta-Analysis. Nutrients. 2021;13(5):1461.
  • Makrgeorgou A, Leonardi-Bee J, Bath-Hextall FJ, Murrell DF, Tang ML, Roberts A, Boyle RJ. Probiotics for treating eczema. Cochrane Database Syst Rev. 2018; 11(11):CD006135.
  • Peng Y, Li A, Yu L, Qin G. The role of probiotics in prevention and treatment for patients with allergic rhinitis: A systematic review. Am J Rhinol Allergy. 2015;29(4):292-8.
  • Du X, Wang L, Wu S, Yuan L, Tang S, Xiang Y, Qu X, Liu H, Qin X, Liu C. Efficacy of probiotic supplementary therapy for asthma, allergic rhinitis, and wheeze: a meta-analysis of randomized controlled trials. Allergy Asthma Proc. 2019;40(4):250-260.
  • Azad MB, Coneys JG, Kozyrskyj AL, Field CJ, Ramsey CD, Becker AB, Friesen C, Abou-Setta AM, Zarychanski R. Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis. BMJ. 2013;347:f6471.
  • Wei X, Jiang P, Liu J, Sun R, Zhu L. Association between probiotic supplementation and asthma incidence in infants: a meta-analysis of randomized controlled trials. J Asthma. 2020;57(2):167-178.
  • Chen N, Liu F, Gao Q, Wang R, Zhang L, Li Y. A Meta-Analysis of Probiotics for the Treatment of Allergic Airway Diseases in Children and Adolescents. Am J Rhinol Allergy. 2022;36(4):480-490.
  • Miraglia Del Giudice M, Maiello N, Decimo F, Fusco N, D' Agostino B, Sullo N, Capasso M, Salpietro V, Gitto E, Ciprandi G, Marseglia GL, Perrone L. Airways allergic inflammation and L. reuterii treatment in asthmatic children. J Biol Regul Homeost Agents. 2012;26(1 Suppl):S35-40.
  • Wang MF, Lin HC, Wang YY, Hsu CH. Treatment of perennial allergic rhinitis with lactic acid bacteria. Pediatr Allergy Immunol. 2004;15(2):152-8.
  • Singh PK, Kaur IP. Synbiotic (probiotic and ginger extract) loaded floating beads: a novel therapeutic option in an experimental paradigm of gastric ulcer. J Pharm Pharmacol 2012;64(2):207-17.
  • Lam EK, Yu L, Wong HP, Wu WK, Shin VY, Tai EK, et al. Probiotic Lactobacillus rhamnosus GG enhances gastric ulcer healing in rats. Eur J Pharmacol 2007; 565(1- 3):171-9
  • Singh PK, Deol PK, Kaur IP. Entrapment of Lactobacillus acidophilus into alginate beads for the effective treatment of cold restraint stress induced gastric ulcer. Food Funct 2012;3(1):83-90.
  • Knackstedt R, Knackstedt T, Gatherwright J. The role of topical probiotics in skin conditions: A systematic review of animal and human studies and implications for future therapies. Exp Dermatol. 2020;29(1):15-21.
  • Knackstedt R, Knackstedt T, Gatherwright J. The role of topical probiotics on wound healing: A review of animal and human studies. Int Wound J. 2020; 17(6):1687-1694.
  • Siempos II, Ntaidou TK, Falagas ME. Impact of the adminis tration of probiotics on the incidence of ventilator-associated pneumonia: A meta-analysis of randomized controlled trials. Crit Care Med 2010; 38: 954–62.
  • Wang J, Liu K, Ariani F, Tao LL, Zhang J, Qu JM. Probio tics for preventing ventilator-associated pneumonia: A syste matic review and meta-analysis of high-quality randomized controlled trials. PLOS One 2013; 8: e83934
  • Vajro P, Mandato C, Licenziati MR, et al. Effects of Lactobacillus rhamnosus strain GG in pediatric obesity-related liver disease. J Pediatr Gastroenterol Nutr 2011; 52:740–743.
  • Alisi A, Bedogni G, Baviera G, et al. Randomised clinical trial: The beneficial effects of VSL#3 in obese children with nonalcoholic steatohepatitis. Aliment Pharmacol Ther 2014; 39:1276–1285
  • Gruner D, Paris S, Schwendicke F. Probiotics for managing caries and periodontitis: Systematic review and meta-analysis. J Dent. 2016; 48:16-25.
  • Kału˙zna-Czapli ´nska, J.; Błaszczyk, S. The level of arabinitol in autistic children after probiotic therapy. Nutrition 2012; 28, 124–126.
  • Grossi E, Melli S, Dunca D, Terruzzi V. Unexpected improvement in core autism spectrum disorder symptoms after long-term treatment with probiotics. SAGE Open Med Case Rep. 2016; 4:2050313X16666231.
Toplam 109 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Beslenme
Bölüm Derleme
Yazarlar

Ece Tüsüz Önata 0000-0002-0180-9093

Öner Özdemir 0000-0002-5338-9561

Proje Numarası Yok
Erken Görünüm Tarihi 19 Mayıs 2024
Yayımlanma Tarihi 30 Nisan 2024
Gönderilme Tarihi 5 Nisan 2024
Kabul Tarihi 23 Nisan 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 8 Sayı: 1

Kaynak Göster

AMA Tüsüz Önata E, Özdemir Ö. Çocuklarda Profilaktik ve Terapötik Probiyotik Kullanımı. J Biotechnol and Strategic Health Res. Nisan 2024;8(1):32-43. doi:10.34084/bshr.1465778
  • Dergimiz Uluslararası hakemli bir dergi olup TÜRKİYE ATIF DİZİNİ, TürkMedline, CrossREF, ASOS index, Google Scholar, JournalTOCs, Eurasian Scientific Journal Index(ESJI), SOBIAD ve ISIindexing dizinlerinde taranmaktadır. TR Dizin(ULAKBİM), SCOPUS, DOAJ için başvurularımızın sonuçlanması beklenmektedir.