Kırk Yaş Altı Mide, Kolorektal ve Pankreas Kanseri Nedeniyle Ameliyat Edilen Hastaların Değerlendirilmesi
Abstract
Amaç: Çalışmamızda malign gastrointestinal sistem tümörlerinin genç erişkinlerde daha ileri evrelerde tanı aldığına ve daha agresif seyirli olduğuna vurgu yaparak erken tanının önemine dikkat çekmek, genç erişkinlerde de malign gastrointestinal sistem tümörü tanısının akılda tutulması gerektiğinin belirtilmesi amaçlanmıştır. Bu amaç ışığında klinik deneyimlerimiz paylaşılmıştır.
Materyal ve Metod: Merkezimizde 2012-2016 yılları arasında ameliyat edilen 40 yaş altı mide, kolorektal ve pankreas kanserli 30 hasta çalışmaya dahil edildi. Hastaların verileri retrospektif olarak dosya kayıtlarından elde edildi. Hastaların tanıları, demografik özellikleri, ailesel kanser öyküleri, yapılan cerrahi ve cerrahi dışı tedavileri, patolojik evrelendirmeleri kayıt edildi. Ayrıca hastaların takip ve survival süreleri kayıt edildi. Bulgular: Kadın erkek oranı 0.57 idi. Ortalama yaş, mide kanseri, kolorektal kanser ve pankreas kanserinde sırasıyla 34± 4.5, 33.7± 4, 30.6± 3.7 idi. Hastalarda en sık görülen bulgular sırasıyla kilo kaybı, karın ağrısı, kabızlık ve rektal kanamaydı. Mide kanseri 13 (% 43), kolorektal kanser 14 (%46), pankreas kanseri 3 (%11) hastada görüldü. Ortalama takip süresi, mide kanseri, kolorektal kanser ve pankreas kanserinde sırasıyla 13.9±7.8, 21.9±15.2, 25.3± 19.7 aydı. Survival oranı, mide kanseri, kolorektal kanser ve pankreas kanserinde sırasıyla 38% 71%, 66% idi. Hastaların 16’sında lenf nodu tutulumu ve ileri evre (evre III- IV) hastalık tespit edildi.Hastaların 4’ü Evre 1, 9’u Evre 2, 10’u Evre 3, 7’si Evre 4 aşamasında tespit edildi.
Sonuç: Malign gastrointestinal sistem tümörler kırk yaş altı genç erişkinlerde de görülmektedir. Mide kanserleri ve kolorektal kanserler sık görülürken, pankreas kanserinin görülme oranı daha düşüktür. Mide kanserlerinde histolojik tip olarak en sık signet ring cell adenocarcinoma görülmektedir. En düşük survival oranı ise mide kanserlerinde görülmüştür.
Keywords
References
- Referans1 Llanos O, Butte JM, Crovari F, Duarte I, Guzmán S. Survival of young patients after gastrectomy for gastric cancer. World J Surg. 2006;30 (1):17-20.
- Referans2 Goldvaser H, Purim O, Kundel Y, Shepshelovich D, Shochat T, Shemesh-Bar L, et al. Colorectal cancer in young patients: is it a distinct clinical entity? Int J ClinOncol. 2016;21(4):684-95.
- Referans3 Levine MS, Laufer I, Thompson JJ. Carcinoma of the gastric cardia in young people. AJR Am J Roentgenol. 1983;140 (1):69-72.
- Referans. Lüttges J, Stigge C, Pacena M, et al. Rare ductal adenocarcinoma of the pancreas in patients younger than age 40 years. Cancer 2004;100 (1):173-82.
- Referans5 O'Connell JB, Maggard MA, Liu JH, Etzioni DA, Livingston EH, Ko CY. Do young colon cancer patients have worse outcomes? World J Surg. 2004;28 (6):558-62.
Evaluation of Younger than Age 40 Years Patients Operated Due to Gastric, Colorectal and Pancreatic Cancer
Abstract
Aim: We aimed to draw attention to the importance of early diagnosis, and to remind that the diagnosis of malign gastrointestinal system tumors should be considered for young adults. For this purpose, our clinical experiences are shared.
Material and Method: Thirty patients under 40 year-old that have been operated in our center between the hear 2012 and 2016 for gastric, colorectal and pancreatic cancers were involved in our study. The data of patients were retrospectively obtained from their files. The diagnoses, demographical characteristics, familial cancer histories, surgeries and nonsurgical treatments, and pathological stages of the patients were recorded. Furthermore, the follow-up and survival durations of the patients were also recorded.. Results: The ratio of female/male was 0.57. Mean age were in gastric, colorectal and pancreas cancer respectively, 34± 4.5, 33.7± 4, 30.6± 3.7. The most frequently seen symptoms are loss of weight, stomachache, constipation, and rectal hemorrhage, respectively. Gastric cancer was seen in 13 (43%) patients, colorectal cancer in 14 (46%) patients, and pancreatic cancer in 3 (11%) patients. Mean followup period were in gastric, colorectal and pancreas cancer respectively,13.9±7.8, 21.9±15.2, 25.3± 19.7 month. Survival rate were in gastric, colorectal and pancreas cancer respectively, 38% 71%, 66%. The lymph node involvement and advanced stage (Stage III and IV) were detected in 16 of the patients. 4 of the patients were diagnosed in Stage 1, 9 in Stage 2, 10 in Stage 3, and 7 in Stage 4.
Conclusion: The malign gastrointestinal system tumors are also seen among younger than age 40 years, young adults. While gastric and colorectal cancers are seen more frequently, the incidence of pancreatic cancer is less. As histological type, the most frequently seen gastric cancer is signet ring cell adenocarcinoma. The lowest rate of survival is seen in gastric cancer cases.
Keywords
References
- Referans1 Llanos O, Butte JM, Crovari F, Duarte I, Guzmán S. Survival of young patients after gastrectomy for gastric cancer. World J Surg. 2006;30 (1):17-20.
- Referans2 Goldvaser H, Purim O, Kundel Y, Shepshelovich D, Shochat T, Shemesh-Bar L, et al. Colorectal cancer in young patients: is it a distinct clinical entity? Int J ClinOncol. 2016;21(4):684-95.
- Referans3 Levine MS, Laufer I, Thompson JJ. Carcinoma of the gastric cardia in young people. AJR Am J Roentgenol. 1983;140 (1):69-72.
- Referans. Lüttges J, Stigge C, Pacena M, et al. Rare ductal adenocarcinoma of the pancreas in patients younger than age 40 years. Cancer 2004;100 (1):173-82.
- Referans5 O'Connell JB, Maggard MA, Liu JH, Etzioni DA, Livingston EH, Ko CY. Do young colon cancer patients have worse outcomes? World J Surg. 2004;28 (6):558-62.
Details
| Journal Section | Articles |
|---|---|
| Authors | |
| Publication Date | December 29, 2016 |
| Submission Date | October 5, 2017 |
| Published in Issue | Year 2016 Volume: 6 Issue: 4 |
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