Case Report
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GASTRIC METASTASIS OF RENAL CELL CARCINOMA: A CASE REPORT

Year 2021, Volume: 28 Issue: 4, 681 - 685, 30.12.2021
https://doi.org/10.17343/sdutfd.871112

Abstract

Primary gastric tumors are encountered more frequently
than metastatic tumors. The gastric metastasis of clear
cell renal cell carcinoma (CCRC) is very rare. We
herein report a case of gastric metastasis of CCRC.
A sixty-year-old man patient underwent a radical
nephrectomy and received adjuvant chemotherapy.
Pulmonary metastasis occurred at the second-year
follow-up, and interferon alpha-2a was used for
relapse. The Computed Tomography examination of
the patient presented with dyspepsia two years after
pulmonary metastases revealed 11 mm thickness in
the (along) gastric wall. Endoscopic examination was
suggestive of a neuroendocrine tumor.
Histopathologic evaluation of endoscopic biopsies
showed tumoral cell groups in a solid pattern composed
of clear, vacuolated cytoplasm. These tumor cells
were positive for RCC, PAX8 CD-10, Vimentin, and
immunohistochemistry findings were similar to the
initial tumor at diagnosis. Finally, the patient was
diagnosed with CCRC's gastric metastasis and treated
with a multi-targeted receptor tyrosine kinase inhibitor.

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Project Number

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Thanks

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References

  • 1. Namikawa T, Hanazaki K. Clinicopathological features and treatment outcomes of metastatic tumors in the stomach. Surgery today. 2014;44(8):1392-9.
  • 2. Sakurai K, Muguruma K, Yamazoe S, Kimura K, Toyokawa T, Amano R, et al. Gastric metastasis from renal cell carcinoma with gastrointestinal bleeding: a case report and review of the literature. International surgery. 2014;99(1):86-90.
  • 3. Green LK. Hematogenous metastases to the stomach. A review of 67 cases. Cancer. 1990;65(7):1596-600.
  • 4. Davis GH, Zollinger RW. Metastatic melanoma of the stomach. The American Journal of Surgery. 1960;99(1):94-6.
  • 5. Gupta K, Miller JD, Li JZ, Russell MW, Charbonneau C. Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review. Cancer treatment reviews. 2008;34(3):193-205.
  • 6. Zhou, Ming, et al. "Protocol for the Examination of Specimens from Patients with Carcinoma of the Ureter and Renal Pelvis." (2017).
  • 7. Kobayashi O, Murakami H, Yoshida T, Cho H, Yoshikawa T, Tsuburaya A, et al. Clinical diagnosis of metastatic gastric tumors: clinicopathologic findings and prognosis of nine patients in a single cancer center. World Journal of Surgery. 2004;28(6):548-51.
  • 8. Pollheimer MJ, Hinterleitner TA, Pollheimer VS, Schlemmer A, Langner C. Renal cell carcinoma metastatic to the stomach: single‐centre experience and literature review. BJU international. 2008;102(3):315-9.
  • 9. Menuck LS, Amberg JR. Metastatic disease involving the stomach. The American Journal of digestive diseases. 1975;20(10):903-13.
  • 10. Oda I, Kondo H, Yamao T, Saito D, Ono H, Gotoda T, et al. Metastatic tumors to the stomach: analysis of 54 patients diagnosed at endoscopy and 347 autopsy cases. Endoscopy. 2001;33(06):507-10.
  • 11. de Oliveira Campoli PM, Ejima FH, Cardoso DMM, da Silva OQ, Santana Filho JB, de Queiroz Barreto PA, et al. Metastatic cancer to the stomach. Gastric Cancer. 2006;9(1):19-25.
  • 12. Eslick GD, Kalantar JS. Gastric metastasis in renal cell carcinoma: a case report and systematic review. Journal of gastrointestinal cancer. 2011;42(4):296-301.
  • 13. Blake M, Owens A, O'Donoghue D, MacErlean D. Embolotherapy for massive upper gastrointestinal haemorrhage secondary to metastatic renal cell carcinoma: report of three cases. Gut. 1995;37(6):835-7.
  • 14. Kim M-Y, Jung H-Y, Choi KD, Song HJ, Lee JH, Kim DH, et al. Solitary synchronous metastatic gastric cancer arising from t1b renal cell carcinoma: a case report and systematic review. Gut and Liver. 2012;6(3):388.
  • 15. De Palma GD, Masone S, Rega M, Simeoli I, Donisi M, Addeo P, et al. Metastatic tumors to the stomach: clinical and endoscopic features. World journal of gastroenterology: WJG. 2006;12(45):7326.
  • 16. Dassen A, Lips D, Hoekstra C, Pruijt J, Bosscha K. FDG-PET has no definite role in preoperative imaging in gastric cancer. European Journal of Surgical Oncology (EJSO). 2009;35(5):449-55.
  • 17. Sakai Y, Kanomata N, Itami H, Kajimoto K, Sakuma T, Ohbayashi C. Signet-ring cell carcinoma of the stomach metastasizing to renal cell carcinoma: a case report and review of the literature. Kobe J Med Sci. 2010;55(6):E122-31.
  • 18. Patel P, Chaganti R, Motzer R. Targeted therapy for metastatic renal cell carcinoma. British Journal of cancer. 2006;94(5):614-9.
  • 19. Cohen H. McGovern fJ: Renal-cell carcinoma. N engl J Med. 2005;353:2477-90
  • 20. SEER Stat Fact Sheets: Kidney and Renal Pelvis http://seer.cancer.gov/statfacts/html/kidrp.html.

RENAL HÜCRELİ KARSİNOMUN MİDEYE METASTAZI: OLGU SUNUMU

Year 2021, Volume: 28 Issue: 4, 681 - 685, 30.12.2021
https://doi.org/10.17343/sdutfd.871112

Abstract

Primer mide tümörlerine, metastatik tümörlerinden
daha sık rastlanır. Berrak hücreli renal hücreli karsinomun
(BHRHK) mideye metastazı çok nadirdir. Bu yazıda
BHRHK’un mideye metastazı olgusunu sunduk.
Altmış yaşında erkek hasta radikal nefrektomi geçirdi
ve adjuvan kemoterapi aldı. Takibinde ikinci yılda
pulmoner metastaz izlendi ve relaps için interferon alfa-
2a kullanıldı. Akciğer metastazlarından iki yıl sonra
dispepsi ile başvuran hastanın bilgisayarlı tomografik
incelemesinde mide duvarında (boyunca) 11 mm
kalınlık saptandı. Endoskopik inceleme nöroendokrin
tümörü düşündürdü.
Histopatolojik incelemede berrak vakuolize sitoplazmalı
solid paternde tümöral hücre grupları gözlendi.
Tümör hücreleri RCC, PAX8, CD10, Vimentin ile pozitif
olup immünhistokimyasal sonuçlar ilk tümör ile
benzerdi. Sonuç olarak olguya BHRHK’un mide metastazı
tanısı verildi ve çok hedefli bir reseptör tirozin
kinaz inhibitörü ile tedavi edildi.

Project Number

-

References

  • 1. Namikawa T, Hanazaki K. Clinicopathological features and treatment outcomes of metastatic tumors in the stomach. Surgery today. 2014;44(8):1392-9.
  • 2. Sakurai K, Muguruma K, Yamazoe S, Kimura K, Toyokawa T, Amano R, et al. Gastric metastasis from renal cell carcinoma with gastrointestinal bleeding: a case report and review of the literature. International surgery. 2014;99(1):86-90.
  • 3. Green LK. Hematogenous metastases to the stomach. A review of 67 cases. Cancer. 1990;65(7):1596-600.
  • 4. Davis GH, Zollinger RW. Metastatic melanoma of the stomach. The American Journal of Surgery. 1960;99(1):94-6.
  • 5. Gupta K, Miller JD, Li JZ, Russell MW, Charbonneau C. Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review. Cancer treatment reviews. 2008;34(3):193-205.
  • 6. Zhou, Ming, et al. "Protocol for the Examination of Specimens from Patients with Carcinoma of the Ureter and Renal Pelvis." (2017).
  • 7. Kobayashi O, Murakami H, Yoshida T, Cho H, Yoshikawa T, Tsuburaya A, et al. Clinical diagnosis of metastatic gastric tumors: clinicopathologic findings and prognosis of nine patients in a single cancer center. World Journal of Surgery. 2004;28(6):548-51.
  • 8. Pollheimer MJ, Hinterleitner TA, Pollheimer VS, Schlemmer A, Langner C. Renal cell carcinoma metastatic to the stomach: single‐centre experience and literature review. BJU international. 2008;102(3):315-9.
  • 9. Menuck LS, Amberg JR. Metastatic disease involving the stomach. The American Journal of digestive diseases. 1975;20(10):903-13.
  • 10. Oda I, Kondo H, Yamao T, Saito D, Ono H, Gotoda T, et al. Metastatic tumors to the stomach: analysis of 54 patients diagnosed at endoscopy and 347 autopsy cases. Endoscopy. 2001;33(06):507-10.
  • 11. de Oliveira Campoli PM, Ejima FH, Cardoso DMM, da Silva OQ, Santana Filho JB, de Queiroz Barreto PA, et al. Metastatic cancer to the stomach. Gastric Cancer. 2006;9(1):19-25.
  • 12. Eslick GD, Kalantar JS. Gastric metastasis in renal cell carcinoma: a case report and systematic review. Journal of gastrointestinal cancer. 2011;42(4):296-301.
  • 13. Blake M, Owens A, O'Donoghue D, MacErlean D. Embolotherapy for massive upper gastrointestinal haemorrhage secondary to metastatic renal cell carcinoma: report of three cases. Gut. 1995;37(6):835-7.
  • 14. Kim M-Y, Jung H-Y, Choi KD, Song HJ, Lee JH, Kim DH, et al. Solitary synchronous metastatic gastric cancer arising from t1b renal cell carcinoma: a case report and systematic review. Gut and Liver. 2012;6(3):388.
  • 15. De Palma GD, Masone S, Rega M, Simeoli I, Donisi M, Addeo P, et al. Metastatic tumors to the stomach: clinical and endoscopic features. World journal of gastroenterology: WJG. 2006;12(45):7326.
  • 16. Dassen A, Lips D, Hoekstra C, Pruijt J, Bosscha K. FDG-PET has no definite role in preoperative imaging in gastric cancer. European Journal of Surgical Oncology (EJSO). 2009;35(5):449-55.
  • 17. Sakai Y, Kanomata N, Itami H, Kajimoto K, Sakuma T, Ohbayashi C. Signet-ring cell carcinoma of the stomach metastasizing to renal cell carcinoma: a case report and review of the literature. Kobe J Med Sci. 2010;55(6):E122-31.
  • 18. Patel P, Chaganti R, Motzer R. Targeted therapy for metastatic renal cell carcinoma. British Journal of cancer. 2006;94(5):614-9.
  • 19. Cohen H. McGovern fJ: Renal-cell carcinoma. N engl J Med. 2005;353:2477-90
  • 20. SEER Stat Fact Sheets: Kidney and Renal Pelvis http://seer.cancer.gov/statfacts/html/kidrp.html.
There are 20 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Case Reports
Authors

Gamze Erkılınç 0000-0003-4704-7415

Sema Bircan 0000-0001-5834-1308

Şirin Başpınar 0000-0002-4947-7569

Şehnaz Evrimler 0000-0002-9907-0011

Altuğ Şenol 0000-0002-1006-9429

Onur Ertunç 0000-0002-4159-1711

Bülent Çetin 0000-0002-4679-2555

Project Number -
Publication Date December 30, 2021
Submission Date January 30, 2021
Acceptance Date April 7, 2021
Published in Issue Year 2021 Volume: 28 Issue: 4

Cite

Vancouver Erkılınç G, Bircan S, Başpınar Ş, Evrimler Ş, Şenol A, Ertunç O, Çetin B. GASTRIC METASTASIS OF RENAL CELL CARCINOMA: A CASE REPORT. Med J SDU. 2021;28(4):681-5.

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