Research Article
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Year 2020, Volume: 20 Issue: 1, 3 - 15, 29.06.2020

Abstract

References

  • 1 KAUKONEN, K M; BAILEY, M; SUZUKI, S, PILCHER, D; BELLOMO, R (2014), Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012, JAMA, 311(13), 1308-1316.
  • 2 GYAWALI, B; RAMAKRISHNA, K; DHAMOON, A S (2019), Sepsis: The evolution in definition, pathophysiology, and management, SAGE Open Med, 7, 2050312119835043.
  • 3 LEVY, M M; ARTIGAS, A; PHILLIPS, G S; RHODES, A; BEALE, R; OSBORN, T; VINCENT, J L; TOWNSEND, S; LEMESHOW, S; DELLINGER, R P (2012), Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study, Lancet Infect Dis, 12(12):919-24.
  • 4 POLAT, G; UGAN, R A; CADIRCI, E; HALICI, Z (2017), Sepsis and Septic Shock: Current Treatment Strategies and New Approaches, Eurasian J Med, 49(1):53-58.
  • 5 ADAM, N; KANDELMAN, S; MANTZ, J; CHRETIEN, F; SHARSHAR, T (2013), Sepsis-induced brain dysfunction, Expert Rev Anti Infect Ther, 11(2): 211-21.
  • 6 COHEN, J (2002), The immunopathogenesis of sepsis, Nature, 420: 885-91.
  • 7 NDUKA, O O; PARRILLO, J E (2009), The pathophysiology of septic shock, Crit Care Clin, 25, 677-702, vii.
  • 8 CINEL, I; OPAL, S M (2009), Molecular biology of inflammation and sepsis: a primer, Crit Care Med, 37: 291-304.
  • 9 POP-BEGAN, V, PAUNESCU, V, GRIGOREAN, V, POP-BEGAN, D; POPESCU, C (2014), Molecular mechanisms in the pathogenesis of sepsis, J Med Life, 7 Spec No, 2:38-41.
  • 10 ALTAN, O; YUCEL, B; ACIKGOZ, Z; SEREMET, C; KOSOGLU, M; TURGAN, N; OZGONUL, A M (2013), Apilarnil reduces fear and advances sexual development in male broilers but has no effect on growth, Br Poult Sci, 54:355-61.
  • 11 BOLATOVNA, K S; RUSTENOV, A; ELEQALIEVA, N; OMIRZAK, T; AKHANOV, U K (2015), Improving reproductive qualities of pigs using the drone brood homogenate, Biol Med (Aligarh), 7, BM-091-15.
  • 12 YÜCEL, B; AÇIKGÖZ, Z; BAYRAKTAR, H; SEREMET, Ç (2011), The effects of apilarnil (drone bee larvae) administration on growth performance and secondary sex characteristics of male broilers, J Anim Vet Adv, 10: 2263-2266.
  • 13 DOGANYIGIT, Z; KUP, F O; SILICI, S; DENIZ, K; YAKAN, B; ATAYOGLU, T (2013), Protective effects of propolis on female rats' histopathological, biochemical and genotoxic changes during LPS induced endotoxemia, Phytomedicine, 20: 632-9.
  • 14 HIRANO, Y; AZIZ, M; YANG, W L; WANG, Z; ZHOU, M; OCHANI, M; KHADER, A; WANG, P (2015), Neutralization of osteopontin attenuates neutrophil migration in sepsis-induced acute lung injury, Crit Care, 19:53.
  • 15 WILHELM, E A; JESSE, C R; ROMAN, S S; NOGUEIRA, C W; SAVEGNAGO, L (2009), Hepatoprotective effect of 3-alkynyl selenophene on acute liver injury induced by D-galactosamine and lipopolysaccharide, Exp Mol Pathol, 87: 20-6.
  • 16 MEDA, A; LAMIEN, C E; MILLOGO, J; ROMITO, M; NACOULMA, O G (2004), Therapeutic uses of honey and honeybee larvae in central Burkina Faso, J Ethnopharmacol, 95: 103-7.
  • 17 DEMIRALAY, R; GURSAN, N; ERDEM, H (2006), Regulation of sepsis-induced apoptosis of pulmonary cells by posttreatment of erdosteine and N-aceylcysteine, Toxicology, 228: 151-61.
  • 18 WANG, J; QIN, Y; MI, X (2016), The protective effects of bone marrow-derived mesenchymal stem cell (BMSC) on LPS-induced acute lung injury via TLR3-mediated IFNs, MAPK and NF-kappaB signaling pathways, Biomed Pharmacother, 79: 176-87.
  • 19 LIU, W A; PANG, G; WANG, S; SUN, A (2017), Protective effect of ulinastatin on severe pulmonary infection under immunosuppression and its molecular mechanism, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 14:3583-3588.
  • 20 CAGLI, K; BAGCI, C; GULEC, M; CENGIZ, B; AKYOL, O; SARI, I; CAVDAR, S; PENCE, S; DINCKAN, H (2005), In vivo effects of caffeic acid phenethyl ester on myocardial ischemia-reperfusion injury and apoptotic changes in rats, Ann Clin Lab Sci, 35:440-8.
  • 21 YULUG, E; TUREDI, S; YILDIRIM, O; YENILMEZ, E; ALIYAZICIOGLU, Y; DEMIR, S; OZER-YAMAN, S; MENTESE, A (2019), Biochemical and morphological evaluation of the effects of propolis on cisplatin induced kidney damage in rats, Biotech Histochem, 94:204-213.
  • 22 KAMIJO, T; SATO, S; KITAMURA, T (2001), Effect of cernitin pollen-extract on experimental nonbacterial prostatitis in rats, Prostate, 49:122-31.
  • 23 SINGH, N P; MCCOY, M T; TICE, R R; SCHNEIDER, E L (1988), A simple technique for quantitation of low levels of DNA damage in individual cells, Exp Cell Res, 175:184-91.
  • 24 FAIRBAIRN, D W; OLIVE, P L; O'NEILL, K L 81995), The comet assay: a comprehensive review, Mutat Res, 339: 37-59.
  • 25 TICE, R R; VASQUEZ, G (1998), Protocol for the application of the pH>13 alkaline sigle cell gel (SCG) assay to the detection of DNA damage in mammalian cells, ILS: The pH>13 Alkaline SCG Assay,Available from: http://cometassay.com/Tice%20and%20Vasques.pdf (Data of access)
  • 26 KLAUDE, M; ERIKSSON, S; NYGREN, J; AHNSTROM, G (1996), The comet assay: mechanisms and technical considerations, Mutat Res, 363: 89-96.
  • 27 HIROSE, H; SAKUMA, N; KAJI, N; SUHARA, T; SEKIJIMA, M; NOJIMA, T; MIYAKOSHI, J (2006), Phosphorylation and gene expression of p53 are not affected in human cells exposed to 2.1425 GHz band CW or W-CDMA modulated radiation allocated to mobile radio base stations, Bioelectromagnetics, 27: 494-504.
  • 28 CAPUCHO, C; SETTE, R; DE SOUZA PREDES, F; DE CASTRO MONTEIRO, J; PIGOSO, A A; BARBIERI, R; DOLDER, M A; SEVERI-AGUIAR, G D (2012). Green Brazilian propolis effects on sperm count and epididymis morphology and oxidative stress, Food Chem Toxicol, 50: 3956-62.
  • 29 RIZK, S M; ZAKI, H F; MINA, M A (2014), Propolis attenuates doxorubicin-induced testicular toxicity in rats, Food Chem Toxicol, 67: 176-86.
  • 30 DOGANYIGIT, Z; SILICI, S; DEMIRTAS, A; KAYA, E; KAYMAK, E (2019), Determination of histological, immunohistochemical and biochemical effects of acute and chronic grayanotoxin III administration in different doses in rats, Environ Sci Pollut Res Int, 26: 1323-1335.

Investigation of Protective Effects of Apilarnil Against Lipopolysaccharide Induced Lung Injury in Rats

Year 2020, Volume: 20 Issue: 1, 3 - 15, 29.06.2020

Abstract

Apilarnil is a bee product that has attracted attention due to its beneficial biological properties recently. This study aimed to investigate the effect of apilarnil (API) on endotoxin-induced lung injury. For the study, 64 adult male Sprague dawley rats were divided into eight groups; control, 0.2, 0.4 and 0.8 g / kg API treated groups by gavage for 10 days, 30 mg / kg lipopolysaccharide (LPS) administered intraperitoneally (single dose), LPS + 0.2, LPS + 0.4 and LPS + 0.8 g / kg API applied groups. In histopathological evaluation, hyperemia, intra-alveolar hemorrhage, cellular infiltration, and increased cellular abnormal proliferation were observed in the lung samples of the LPS group. It was found that the lung samples of LPS + 0,4 and LPS + 0,8 API groups decreased statistically significant compared to the LPS group. The number of TUNEL positive cells observed in both LPS and API treated groups showed a statistically significant decrease compared to the LPS group. In comet test, 0,8 API group was found to be reduced more in tail % DNA and tail length when LPS + API treated groups were compared with LPS group. In conclusion, the API applied to rats can prevent LPS-induced lung injury.

References

  • 1 KAUKONEN, K M; BAILEY, M; SUZUKI, S, PILCHER, D; BELLOMO, R (2014), Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012, JAMA, 311(13), 1308-1316.
  • 2 GYAWALI, B; RAMAKRISHNA, K; DHAMOON, A S (2019), Sepsis: The evolution in definition, pathophysiology, and management, SAGE Open Med, 7, 2050312119835043.
  • 3 LEVY, M M; ARTIGAS, A; PHILLIPS, G S; RHODES, A; BEALE, R; OSBORN, T; VINCENT, J L; TOWNSEND, S; LEMESHOW, S; DELLINGER, R P (2012), Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study, Lancet Infect Dis, 12(12):919-24.
  • 4 POLAT, G; UGAN, R A; CADIRCI, E; HALICI, Z (2017), Sepsis and Septic Shock: Current Treatment Strategies and New Approaches, Eurasian J Med, 49(1):53-58.
  • 5 ADAM, N; KANDELMAN, S; MANTZ, J; CHRETIEN, F; SHARSHAR, T (2013), Sepsis-induced brain dysfunction, Expert Rev Anti Infect Ther, 11(2): 211-21.
  • 6 COHEN, J (2002), The immunopathogenesis of sepsis, Nature, 420: 885-91.
  • 7 NDUKA, O O; PARRILLO, J E (2009), The pathophysiology of septic shock, Crit Care Clin, 25, 677-702, vii.
  • 8 CINEL, I; OPAL, S M (2009), Molecular biology of inflammation and sepsis: a primer, Crit Care Med, 37: 291-304.
  • 9 POP-BEGAN, V, PAUNESCU, V, GRIGOREAN, V, POP-BEGAN, D; POPESCU, C (2014), Molecular mechanisms in the pathogenesis of sepsis, J Med Life, 7 Spec No, 2:38-41.
  • 10 ALTAN, O; YUCEL, B; ACIKGOZ, Z; SEREMET, C; KOSOGLU, M; TURGAN, N; OZGONUL, A M (2013), Apilarnil reduces fear and advances sexual development in male broilers but has no effect on growth, Br Poult Sci, 54:355-61.
  • 11 BOLATOVNA, K S; RUSTENOV, A; ELEQALIEVA, N; OMIRZAK, T; AKHANOV, U K (2015), Improving reproductive qualities of pigs using the drone brood homogenate, Biol Med (Aligarh), 7, BM-091-15.
  • 12 YÜCEL, B; AÇIKGÖZ, Z; BAYRAKTAR, H; SEREMET, Ç (2011), The effects of apilarnil (drone bee larvae) administration on growth performance and secondary sex characteristics of male broilers, J Anim Vet Adv, 10: 2263-2266.
  • 13 DOGANYIGIT, Z; KUP, F O; SILICI, S; DENIZ, K; YAKAN, B; ATAYOGLU, T (2013), Protective effects of propolis on female rats' histopathological, biochemical and genotoxic changes during LPS induced endotoxemia, Phytomedicine, 20: 632-9.
  • 14 HIRANO, Y; AZIZ, M; YANG, W L; WANG, Z; ZHOU, M; OCHANI, M; KHADER, A; WANG, P (2015), Neutralization of osteopontin attenuates neutrophil migration in sepsis-induced acute lung injury, Crit Care, 19:53.
  • 15 WILHELM, E A; JESSE, C R; ROMAN, S S; NOGUEIRA, C W; SAVEGNAGO, L (2009), Hepatoprotective effect of 3-alkynyl selenophene on acute liver injury induced by D-galactosamine and lipopolysaccharide, Exp Mol Pathol, 87: 20-6.
  • 16 MEDA, A; LAMIEN, C E; MILLOGO, J; ROMITO, M; NACOULMA, O G (2004), Therapeutic uses of honey and honeybee larvae in central Burkina Faso, J Ethnopharmacol, 95: 103-7.
  • 17 DEMIRALAY, R; GURSAN, N; ERDEM, H (2006), Regulation of sepsis-induced apoptosis of pulmonary cells by posttreatment of erdosteine and N-aceylcysteine, Toxicology, 228: 151-61.
  • 18 WANG, J; QIN, Y; MI, X (2016), The protective effects of bone marrow-derived mesenchymal stem cell (BMSC) on LPS-induced acute lung injury via TLR3-mediated IFNs, MAPK and NF-kappaB signaling pathways, Biomed Pharmacother, 79: 176-87.
  • 19 LIU, W A; PANG, G; WANG, S; SUN, A (2017), Protective effect of ulinastatin on severe pulmonary infection under immunosuppression and its molecular mechanism, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 14:3583-3588.
  • 20 CAGLI, K; BAGCI, C; GULEC, M; CENGIZ, B; AKYOL, O; SARI, I; CAVDAR, S; PENCE, S; DINCKAN, H (2005), In vivo effects of caffeic acid phenethyl ester on myocardial ischemia-reperfusion injury and apoptotic changes in rats, Ann Clin Lab Sci, 35:440-8.
  • 21 YULUG, E; TUREDI, S; YILDIRIM, O; YENILMEZ, E; ALIYAZICIOGLU, Y; DEMIR, S; OZER-YAMAN, S; MENTESE, A (2019), Biochemical and morphological evaluation of the effects of propolis on cisplatin induced kidney damage in rats, Biotech Histochem, 94:204-213.
  • 22 KAMIJO, T; SATO, S; KITAMURA, T (2001), Effect of cernitin pollen-extract on experimental nonbacterial prostatitis in rats, Prostate, 49:122-31.
  • 23 SINGH, N P; MCCOY, M T; TICE, R R; SCHNEIDER, E L (1988), A simple technique for quantitation of low levels of DNA damage in individual cells, Exp Cell Res, 175:184-91.
  • 24 FAIRBAIRN, D W; OLIVE, P L; O'NEILL, K L 81995), The comet assay: a comprehensive review, Mutat Res, 339: 37-59.
  • 25 TICE, R R; VASQUEZ, G (1998), Protocol for the application of the pH>13 alkaline sigle cell gel (SCG) assay to the detection of DNA damage in mammalian cells, ILS: The pH>13 Alkaline SCG Assay,Available from: http://cometassay.com/Tice%20and%20Vasques.pdf (Data of access)
  • 26 KLAUDE, M; ERIKSSON, S; NYGREN, J; AHNSTROM, G (1996), The comet assay: mechanisms and technical considerations, Mutat Res, 363: 89-96.
  • 27 HIROSE, H; SAKUMA, N; KAJI, N; SUHARA, T; SEKIJIMA, M; NOJIMA, T; MIYAKOSHI, J (2006), Phosphorylation and gene expression of p53 are not affected in human cells exposed to 2.1425 GHz band CW or W-CDMA modulated radiation allocated to mobile radio base stations, Bioelectromagnetics, 27: 494-504.
  • 28 CAPUCHO, C; SETTE, R; DE SOUZA PREDES, F; DE CASTRO MONTEIRO, J; PIGOSO, A A; BARBIERI, R; DOLDER, M A; SEVERI-AGUIAR, G D (2012). Green Brazilian propolis effects on sperm count and epididymis morphology and oxidative stress, Food Chem Toxicol, 50: 3956-62.
  • 29 RIZK, S M; ZAKI, H F; MINA, M A (2014), Propolis attenuates doxorubicin-induced testicular toxicity in rats, Food Chem Toxicol, 67: 176-86.
  • 30 DOGANYIGIT, Z; SILICI, S; DEMIRTAS, A; KAYA, E; KAYMAK, E (2019), Determination of histological, immunohistochemical and biochemical effects of acute and chronic grayanotoxin III administration in different doses in rats, Environ Sci Pollut Res Int, 26: 1323-1335.
There are 30 citations in total.

Details

Primary Language English
Subjects Structural Biology, Agricultural Engineering
Journal Section Articles
Authors

Züleyha Doğanyiğit

Emin Kaymak This is me

Aslı Okan

Dilek Pandır

Sibel Silici

Publication Date June 29, 2020
Submission Date October 30, 2019
Acceptance Date June 26, 2020
Published in Issue Year 2020 Volume: 20 Issue: 1

Cite

APA Doğanyiğit, Z., Kaymak, E., Okan, A., Pandır, D., et al. (2020). Investigation of Protective Effects of Apilarnil Against Lipopolysaccharide Induced Lung Injury in Rats. Mellifera, 20(1), 3-15.
AMA Doğanyiğit Z, Kaymak E, Okan A, Pandır D, Silici S. Investigation of Protective Effects of Apilarnil Against Lipopolysaccharide Induced Lung Injury in Rats. mellifera. June 2020;20(1):3-15.
Chicago Doğanyiğit, Züleyha, Emin Kaymak, Aslı Okan, Dilek Pandır, and Sibel Silici. “Investigation of Protective Effects of Apilarnil Against Lipopolysaccharide Induced Lung Injury in Rats”. Mellifera 20, no. 1 (June 2020): 3-15.
EndNote Doğanyiğit Z, Kaymak E, Okan A, Pandır D, Silici S (June 1, 2020) Investigation of Protective Effects of Apilarnil Against Lipopolysaccharide Induced Lung Injury in Rats. Mellifera 20 1 3–15.
IEEE Z. Doğanyiğit, E. Kaymak, A. Okan, D. Pandır, and S. Silici, “Investigation of Protective Effects of Apilarnil Against Lipopolysaccharide Induced Lung Injury in Rats”, mellifera, vol. 20, no. 1, pp. 3–15, 2020.
ISNAD Doğanyiğit, Züleyha et al. “Investigation of Protective Effects of Apilarnil Against Lipopolysaccharide Induced Lung Injury in Rats”. Mellifera 20/1 (June 2020), 3-15.
JAMA Doğanyiğit Z, Kaymak E, Okan A, Pandır D, Silici S. Investigation of Protective Effects of Apilarnil Against Lipopolysaccharide Induced Lung Injury in Rats. mellifera. 2020;20:3–15.
MLA Doğanyiğit, Züleyha et al. “Investigation of Protective Effects of Apilarnil Against Lipopolysaccharide Induced Lung Injury in Rats”. Mellifera, vol. 20, no. 1, 2020, pp. 3-15.
Vancouver Doğanyiğit Z, Kaymak E, Okan A, Pandır D, Silici S. Investigation of Protective Effects of Apilarnil Against Lipopolysaccharide Induced Lung Injury in Rats. mellifera. 2020;20(1):3-15.