Research Article
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Investigation of Insulin-Like Growth Factor 1 Receptor Expression in Cases of Sacrococcygeal Pilonidal Sinus

Year 2023, Volume: 5 Issue: 3, 483 - 8, 18.09.2023

Sema Avcı Sevinç Şahin Cemre Nur Balcı

https://doi.org/10.37990/medr.1285358

Abstract

Aim: This study aims to determine the role of IGF-1R in the etiology of sacrococcygeal pilonidal sinus and to evaluate the findings regarding its contribution to treatment.

Material and Methods: The general structure of skin and connective tissue components in healthy and lesioned tissue sections of sacrococcygeal pilonidal sinus cases was evaluated by Masson trichrome staining. In addition, the expression of IGF-1R protein in healthy and pilonidal sinus tissue was determined by immunohistochemical staining.

Results: It was observed that the epidermis of the pilonidal sinus was thinned compared to the healthy area, and the hair follicle structures and connective tissue components deteriorated. IGF-1R expression was significantly decreased in basal keratinocytes in sacrococcygeal pilonidal sinus tissues.

Conclusion: It is thought that IGF-1R may be involved in the etiology of sacrococcygeal pilonidal sinus, and more data is needed in terms of its contribution to treatment.

Keywords

Sacrococcygeal Pilonidal Sinus IGF-1R keratinocytes

Project Number

YOK

References

  • 1. Nixon AT, Garza RF. Pilonidal cyst and sinus. StatPearls. 2023.
  • 2. de Parades V, Bouchard D, Janier M, Berger A. Pilonidal sinus disease. J Visc Surg. 2013;150:237-47.
  • 3. Hap W, Frejlich E, Rudno-Rudzinska J, et al. Pilonidal sinus: finding the righttrack for treatment. Pol Przegl Chir. 2017;89:68-75.
  • 4. Halleran DR, Onwuka AJ, Lawrence AE, et al. Laser hair depilation in the treatment of pilonidal disease: a systematic review. Surg Infect (Larchmt). 2018;19:566-72.
  • 5. Can A. Hair follicle stem cells and intrafollicular homeostasis. Turkderm-Turk Arch Dermatol Venereol. 2014;48:6-9.
  • 6. Garza LA, Liu Y, Yang Z, et al. Prostaglandin d2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Sci Transl Med. 2012;4:126ra34.
  • 7. Muraguchi T, Nanba D, Nishimura EK, Tashiro T. Igf-1r deficiency in human keratinocytes disrupts epidermal homeostasis and stem cell maintenance. J Dermatol Sci. 2019;94:298-305.
  • 8. Loesch MM, Collier AE, Southern DH, et al. Insulin-like growth factor-1 receptor regulates repair of ultraviolet b-induced dna damage in human keratinocytes in vivo. Mol Oncol. 2016;10:1245-54.
  • 9. Duchateau J, De Mol J, Bostoen H, Allegaert W. Pilonidal sinus. Excision--marsupialization--phenolization? Acta Chir Belg. 1985;85:325-8.
  • 10. Chintapatla S, Safarani N, Kumar S, Haboubi N. Sacrococcygeal pilonidal sinus: historical review, pathological insight and surgical options. Tech Coloproctol. 2003;7:3-8.
  • 11. Karydakis GE. Easy and successful treatment of pilonidal sinus after explanation of its causative process. Aust NZJ Surg. 1992;62:385-9.
  • 12. Mustafa G, Akber G, Lodhi JK, et al. Umbilical pilonidal sinus. J Ayub Med Coll Abbottabad. 2014;26:100-1. 13. Isik A, Idiz O, Firat D. Novel approaches in pilonidal sinus treatment. Prague Med Rep. 2016;117:145-52.
  • 14. Weale FE. The hair of the pilonidal sinus. Lancet. 1955;268:230-1.
  • 15. Stelzner F. Causes of pilonidal sinus and pyoderma fistulans sinifica. Langenbecks Arch Chir. 1984;362:105-18.
  • 16. Dahl HD, Henrich MH. Light and scanning electron microscopy study of the pathogenesis of pilonidal sinus and anal fistula. Langenbecks Arch Chir. 1992;377:118-24.
  • 17. Gosselink MP, Jenkins L, Toh JWT, et al. Scanning electron microscope imaging of pilonidal disease. Tech Coloproctol. 2017;21:905-6.
  • 18. Yousef H, Alhajj M, Sharma S. Anatomy, skin (integument), epidermis. StatPearls. 2023.
  • 19. Alyoussef A. The therapeutic effects of blocking igf-r1 on mice model of skin cancer. J Dermatolog Treat. 2021;32:803-11.
  • 20. Federici M, Porzio O, Zucaro L, et al. Distribution of insulin/insulin-like growth factor-I hybrid receptors in human tissues. Mol Cell Endocrinol. 1997;129:121-6.
  • 21. Forbes BE, Blyth AJ, Wit JM. Disorders of igfs and igf-1r signaling pathways. Mol Cell Endocrinol. 2020;518:111035.
  • 22. Annunziata M, Granata R, Ghigo E. The igf system. Acta Diabetol. 2011;48:1-9.
  • 23. Le Roith D. The insulin-like growth factor system. Exp Diabesity Res. 2003;4:205-12.
  • 24. Pardee AB. G1 events and regulation of cell proliferation. Science. 1989;246:603-8.
  • 25. Rudman SM, Philpott MP, Thomas GA, Kealey T. The role of igf-i in human skin and its appendages: morphogen as well as mitogen? J Invest Dermatol. 1997;109:770-7.
  • 26. Lewis DA, Travers JB, Somani AK, Spandau DF. The igf-1/igf-1r signaling axis in the skin: a new role for the dermis in aging-associated skin cancer. Oncogene. 2010;29:1475-85.
  • 27. Liu JP, Baker J, Perkins AS, et al. Mice carrying null mutations of the genes encoding insulin-like growth factor i (igf-1) and type 1 igf receptor (igf1r). Cell. 1993;75:59-72.
  • 28. Barkan AL, Beitins IZ, Kelch RP. Plasma insulin-like growth factor-I/somatomedin-c in acromegaly: correlation with the degree of growth hormone hypersecretion. J Clin Endocrinol Metab. 1988;67:69-73.
  • 29. Selman C, Lingard S, Choudhury AI, et al. Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J. 2008;22:807-18.
  • 30. Knuever J, Willenborg S, Ding X, et al. Myeloid cell-restricted insulin/igf-1 receptor deficiency protects against skin inflammation. J Immunol. 2015;195:5296-308.

Year 2023, Volume: 5 Issue: 3, 483 - 8, 18.09.2023

Sema Avcı Sevinç Şahin Cemre Nur Balcı

https://doi.org/10.37990/medr.1285358

Abstract

Supporting Institution

YOK

Project Number

YOK

Thanks

YOK

References

  • 1. Nixon AT, Garza RF. Pilonidal cyst and sinus. StatPearls. 2023.
  • 2. de Parades V, Bouchard D, Janier M, Berger A. Pilonidal sinus disease. J Visc Surg. 2013;150:237-47.
  • 3. Hap W, Frejlich E, Rudno-Rudzinska J, et al. Pilonidal sinus: finding the righttrack for treatment. Pol Przegl Chir. 2017;89:68-75.
  • 4. Halleran DR, Onwuka AJ, Lawrence AE, et al. Laser hair depilation in the treatment of pilonidal disease: a systematic review. Surg Infect (Larchmt). 2018;19:566-72.
  • 5. Can A. Hair follicle stem cells and intrafollicular homeostasis. Turkderm-Turk Arch Dermatol Venereol. 2014;48:6-9.
  • 6. Garza LA, Liu Y, Yang Z, et al. Prostaglandin d2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Sci Transl Med. 2012;4:126ra34.
  • 7. Muraguchi T, Nanba D, Nishimura EK, Tashiro T. Igf-1r deficiency in human keratinocytes disrupts epidermal homeostasis and stem cell maintenance. J Dermatol Sci. 2019;94:298-305.
  • 8. Loesch MM, Collier AE, Southern DH, et al. Insulin-like growth factor-1 receptor regulates repair of ultraviolet b-induced dna damage in human keratinocytes in vivo. Mol Oncol. 2016;10:1245-54.
  • 9. Duchateau J, De Mol J, Bostoen H, Allegaert W. Pilonidal sinus. Excision--marsupialization--phenolization? Acta Chir Belg. 1985;85:325-8.
  • 10. Chintapatla S, Safarani N, Kumar S, Haboubi N. Sacrococcygeal pilonidal sinus: historical review, pathological insight and surgical options. Tech Coloproctol. 2003;7:3-8.
  • 11. Karydakis GE. Easy and successful treatment of pilonidal sinus after explanation of its causative process. Aust NZJ Surg. 1992;62:385-9.
  • 12. Mustafa G, Akber G, Lodhi JK, et al. Umbilical pilonidal sinus. J Ayub Med Coll Abbottabad. 2014;26:100-1. 13. Isik A, Idiz O, Firat D. Novel approaches in pilonidal sinus treatment. Prague Med Rep. 2016;117:145-52.
  • 14. Weale FE. The hair of the pilonidal sinus. Lancet. 1955;268:230-1.
  • 15. Stelzner F. Causes of pilonidal sinus and pyoderma fistulans sinifica. Langenbecks Arch Chir. 1984;362:105-18.
  • 16. Dahl HD, Henrich MH. Light and scanning electron microscopy study of the pathogenesis of pilonidal sinus and anal fistula. Langenbecks Arch Chir. 1992;377:118-24.
  • 17. Gosselink MP, Jenkins L, Toh JWT, et al. Scanning electron microscope imaging of pilonidal disease. Tech Coloproctol. 2017;21:905-6.
  • 18. Yousef H, Alhajj M, Sharma S. Anatomy, skin (integument), epidermis. StatPearls. 2023.
  • 19. Alyoussef A. The therapeutic effects of blocking igf-r1 on mice model of skin cancer. J Dermatolog Treat. 2021;32:803-11.
  • 20. Federici M, Porzio O, Zucaro L, et al. Distribution of insulin/insulin-like growth factor-I hybrid receptors in human tissues. Mol Cell Endocrinol. 1997;129:121-6.
  • 21. Forbes BE, Blyth AJ, Wit JM. Disorders of igfs and igf-1r signaling pathways. Mol Cell Endocrinol. 2020;518:111035.
  • 22. Annunziata M, Granata R, Ghigo E. The igf system. Acta Diabetol. 2011;48:1-9.
  • 23. Le Roith D. The insulin-like growth factor system. Exp Diabesity Res. 2003;4:205-12.
  • 24. Pardee AB. G1 events and regulation of cell proliferation. Science. 1989;246:603-8.
  • 25. Rudman SM, Philpott MP, Thomas GA, Kealey T. The role of igf-i in human skin and its appendages: morphogen as well as mitogen? J Invest Dermatol. 1997;109:770-7.
  • 26. Lewis DA, Travers JB, Somani AK, Spandau DF. The igf-1/igf-1r signaling axis in the skin: a new role for the dermis in aging-associated skin cancer. Oncogene. 2010;29:1475-85.
  • 27. Liu JP, Baker J, Perkins AS, et al. Mice carrying null mutations of the genes encoding insulin-like growth factor i (igf-1) and type 1 igf receptor (igf1r). Cell. 1993;75:59-72.
  • 28. Barkan AL, Beitins IZ, Kelch RP. Plasma insulin-like growth factor-I/somatomedin-c in acromegaly: correlation with the degree of growth hormone hypersecretion. J Clin Endocrinol Metab. 1988;67:69-73.
  • 29. Selman C, Lingard S, Choudhury AI, et al. Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J. 2008;22:807-18.
  • 30. Knuever J, Willenborg S, Ding X, et al. Myeloid cell-restricted insulin/igf-1 receptor deficiency protects against skin inflammation. J Immunol. 2015;195:5296-308.
There are 29 citations in total.

Details

Primary Language English
Subjects Surgery
Journal Section Original Articles
Authors

Sema Avcı 0000-0002-2860-5592

Sevinç Şahin 0000-0002-9409-8138

Cemre Nur Balcı 0000-0002-3481-2782

Project Number YOK
Early Pub Date June 19, 2023
Publication Date September 18, 2023
Acceptance Date May 16, 2023
Published in Issue Year 2023 Volume: 5 Issue: 3

Cite

AMA Avcı S, Şahin S, Balcı CN. Investigation of Insulin-Like Growth Factor 1 Receptor Expression in Cases of Sacrococcygeal Pilonidal Sinus. Med Records. September 2023;5(3):483-8. doi:10.37990/medr.1285358
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Chief Editors

Assoc. Prof. Zülal Öner
Address: İzmir Bakırçay University, Department of Anatomy, İzmir, Türkiye

Assoc. Prof. Deniz Şenol
Address: Düzce University, Department of Anatomy, Düzce, Türkiye

E-mail: medrecsjournal@gmail.com

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