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Acı Su Koşullarında Avrupa Deniz Levreklerinde (Dicentrarchus labrax) Mycobacterium marinum Enfeksiyonu

Year 2023, Volume: 13 Issue: 4, 1570 - 1580, 15.12.2023

Ezgi Dinçtürk Ttansel Tanrıkul

https://doi.org/10.31466/kfbd.1313208

Abstract

Mikobakteriyozis, hem balıkları hem de insanları etkileyen, iyi bilinen zoonotik bir hastalıktır. Patojen Mycobacterium marinum, balıklarda sistemik ve ölümcül hastalıklara neden olur, çiftlik ve akvaryum türlerinde gözlenebilir. Bu çalışmada, yaygın klinik ve patolojik bulgularla Avrupa deniz levreğinde (Dicentrarchus labrax) M.marinum enfeksiyonu acı su koşullarında (3.92 ‰) saptanmıştır. Deride ülserler, büyümüş dalak ve karaciğerde granülomlar gözlenmiştir. Patojen, Löwenstein-Jensen (L-J) besiyerinde izole edilmiş ve moleküler tanımlama ile de M.marinum olduğu doğrulanmıştır. Histopatolojik incelemede çok sayıda granülom saptanmıştır. Avrupa deniz levreği, Türkiye'de en çok yetiştirilen balık türlerinden biridir ve bu çalışma, Avrupa deniz levreğinde klinik ve patolojik bulgularla acı su koşullarından mikobakteriyozu ayrıntılı olarak sunmaktadır.

Keywords

Mikobakteriyozis su ürünleri yetiştiriciliği Avrupa deniz levreği granülom

References

  • Arda, M. (2006). Temel mikrobiyoloji. Medisan Yayınevi, Ankara.
  • Aronson, J. D. (1926). Spontaneous tuberculosis in salt water fish. The journal of infectious diseases, 315-320.
  • Aubry, A., Chosidow, O., Caumes, E., Robert, J., and Cambau, E. (2002). Sixty-three cases of Mycobacterium marinum infection: clinical features, treatment, and antibiotic susceptibility of causative isolates. Archives of Internal Medicine, 162(15), 1746-1752.
  • Austin, B., and Austin, D. A. (2007). Bacterial Fish Pathogens (p. 652). Heidelberg: Springer.
  • Avsever, M. L., Çavuşoğlu, C., Günen, M. Z., Yazıcıoğlu, Ö., Eskiizmirliler, S., Didinen, B. I., Tunalıgil, S., Erdal, G., and Özden, M. (2014). The first report of Mycobacterium marinum isolated from cultured meagre, Argyrosomus regius. Bulletin of the European Association of Fish Pathologists, 34(4).
  • Avsever, M. L., Çavuşoğlu, C., Eskiizmirliler, S., Türe, M., Korun, J., and Çamkerten, I. (2016). First isolation of Mycobacterium marinum from sea bass (Dicentrarchus labrax) and gilthead sea bream (Sparus auratus) cultured in Turkey. Bulletin of the European Association of Fish Pathologists, 36(5), 193
  • Brocklebank, J., Raverty, S., and Robinson, J. (2003). Mycobacteriosis in Atlantic salmon farmed in British Columbia. The Canadian Veterinary Journal, 44(6), 486.
  • Clark, R. B., Spector, H., Friedman, D. M., Oldrati, K. J., Young, C. L., and Nelson, S. C. (1990). Osteomyelitis and synovitis produced by Mycobacterium marinum in a fisherman. Journal of Clinical Microbiology, 28(11), 2570-2572.
  • Colorni, A. (1992). A systemic mycobacteriosis in the European sea bass Dicentrarchus labrax cultured in Eilat (Red Sea). Israeli Journal of Aquaculture - Bamidgeh, 44(3), 75-81.
  • Colorni, A., Avtalion, R., Knibb, W., Berger, E., Colorni, B., and Timan, B. (1998). Histopathology of sea bass (Dicentrarchus labrax) experimentally infected with Mycobacterium marinum and treated with streptomycin and garlic (Allium sativum) extract. Aquaculture, 160(1-2), 1-17.
  • Culling, A. F., Allison, T. R., and Barr, T. W. (1985). Cellular Pathology Technique, 4th Edition, London: ButterworthandCo.(Publ.)
  • Das, S., Pettersson, B. M., Behra, P. R. K., Mallick, A., Cheramie, M., Ramesh, M., Shirreff, L., DuCote, T., Dasgupta, S., Ennis, D. G., and Kirsebom, L. (2018). Extensive genomic diversity among Mycobacterium marinum strains revealed by whole genome sequencing. Scientific Reports, 8(1), 1-15.
  • Diamant, A., Banet, A., Ucko, M., Colorni, A., Knibb, W., and Kvitt, H. (2000). Mycobacteriosis in wild rabbitfish Siganus rivulatus associated with cage farming in the Gulf of Eilat, Red Sea. Diseases of Aquatic Organisms, 39(3), 211-219.
  • Dos Santos, N. M. S., Do Vale, A., Sousa, M. J., and Silva, M. T. (2002). Mycobacterial infection in farmed turbot Scophthalmus maximus. Diseases of Aquatic Organisms, 52(1), 87-91.
  • Ferreira, M., Caetano, M., Antunes, P., Costa, J., Gil, O.,Bandarra, N., Pousão-Ferreira, P., Vale, C., Reis Henriquesa, M. A. (2010). Assessment of contaminantsand biomarkers of exposure in wild and farmed sea bass. Ecotoxicology and Environmental Safety, 73, 579–588. https://doi.org/10.1016/j.ecoenv.2010.01.019
  • Gauthier, D. T., and Rhodes, M. W. (2009). Mycobacteriosis in fishes: a review. The Veterinary Journal, 180(1), 33-47.
  • Hashish, E., Merwad, A., Elgaml, S., Amer, A., Kamal, H., Elsadek, A., Marei, A., and Sitohy, M. (2018). Mycobacterium marinum infection in fish and man: epidemiology, pathophysiology and management; a review. Veterinary Quarterly, 38(1), 35-46.
  • Hedrick, R. P., McDowell, T., and Groff, J. (1987). Mycobacteriosis in cultured striped bass from California. Journal of Wildlife Diseases, 23(3), 391-395.
  • Jacobs, J. M., Stine, C. B., Baya, A. M., and Kent, M. L. (2009). A review of mycobacteriosis in marine fish. Journal of Fish Diseases, 32(2), 119-130.
  • Keller, C., Wenker, C., Jermann, T., Hirschi, R., Schildger, B., Meier, R., and Schmidt-Posthaus, H. (2018). Piscine mycobacteriosis–Involvement of bacterial species and reflection in pathology. Schweizer Archiv für Tierheilkunde, 160(6), 385-393.
  • Kent, M. L., Watral, V., Wu, M., and Bermudez, L. E. (2006). In vivo and in vitro growth of Mycobacterium marinum at homoeothermic temperatures. FEMS Microbiology Letters, 257(1), 69-75.
  • Korun, J., Olgac, V., Akgun-Dar, K., Colorni, A., and Diamant, A. (2005). Mycobacteriosis in European sea bass, l., cultured in Turkey. The Israeli Journal of Aquaculture – Bamidgeh 57(4), 215-222.
  • Kurokawa, S., Kabayama, J., Fukuyasu, T., Hwang, S. D., Park, C. I., Park, S. B.,Castillo, C.S., Hikima, J., Jung, T. S., Kondo, H., Hirono, I., Takeyama, H., and Aoki, T. (2013). Bacterial classification of fish-pathogenic Mycobacterium species by multigene phylogenetic analyses and MALDI Biotyper identification system. Marine Biotechnology, 15, 340-348.
  • Lansdell, W., Dixon, B., Smith, N., and Benjamin, L. (1993). Communications: Isolation of several mycobacterium species from fish. Journal of Aquatic Animal Health, 5(1), 73-76.
  • Lawler, A. R. (1994). Human Myobacterium marinum Aronson infections. Journal of Aquariculture and Aquatic Sciences, 6(4), 93-95.
  • Ostland, V. E., Watral, V., Whipps, C. M., Austin, F. W., St-Hilaire, S., Westerman, M. E., and Kent, M. L. (2008). Biochemical, molecular, and virulence characteristics of select Mycobacterium marinum isolates in hybrid striped bass Morone chrysops× M. saxatilis and zebrafish Danio rerio. Diseases of Aquatic Organisms, 79(2), 107-118.
  • Peña Merino, L., Mendieta-Eckert, M., Méndez Maestro, I., and Gardeazabal García, J. (2020). Infección por Mycobacterium marinum en una paciente en tratamiento con adalimumab. Actas dermo-sifiliogr.(Ed. impr.), 525-526.
  • Pidot, S. J., Asiedu, K., Käser, M., Fyfe, J. A., and Stinear, T. P. (2010). Mycobacterium ulcerans and other mycolactone-producing mycobacteria should be considered a single species. PLoS Neglected Tropical Diseases, 4(7), e663.
  • Qi, W., Käser, M., Röltgen, K., Yeboah-Manu, D., & Pluschke, G. (2009). Genomic diversity and evolution of Mycobacterium ulcerans revealed by next-generation sequencing. PLoS pathogens, 5(9), e1000580.
  • Rallis, E., and Koumantaki-Mathioudaki, E. (2007). Treatment of Mycobacterium marinum cutaneous infections. Expert Opinion on Pharmacotherapy, 8(17), 2965-2978.
  • Ravid-Peretz, S., Colorni, A., Sharon, G., and Ucko, M. (2019). Vaccination of European sea bass Dicentrarchus labrax with avirulent Mycobacterium marinum (iipA:: kan mutant). Fish & Shellfish Immunology, 90, 317-327.
  • Roberts, R. J. (2001). The bacteriology of teleosts. Fish pathology, (Ed. 3).
  • Slany, M., Makovcova, J., Jezek, P., Bodnarova, M., and Pavlik, I. (2014). Relative prevalence of Mycobacterium marinum in fish collected from aquaria and natural freshwaters in central Europe. Journal of Fish Diseases, 37(6), 527-533.
  • Tamura, K., Stecher, G., Kumar, S. (2021) MEGA11: Molecular Evolutionary Genetics Analysis version 11. Molecular Biology and Evolution 38:3022-3027
  • Tanrıkul, T.,T and Dinçtürk, E. (2021). A New Outbreak in Sea Bass Farming in Turkey: Aeromonas veronii. Journal of the Hellenic Veterinary Medical Society, 72(3), 3051-3058.
  • Timur, G., Ürkü, Ç., Çanak, Ö. G., Genç, E., Erturan, Z. (2015). Systemic mycobacteriosis caused by Mycobacterium marinum in farmed meagre (Argyrosomus regius), in Turkey. Israeli Journal of Aquaculture - Bamidgeh, 67, 1–8.
  • TUIK (2023). Fishery Statistics (https://data.tuik.gov.tr/Kategori/GetKategori?p=tarim-111&dil=1) (September / 2023).
  • Ucko, M., Colorni, A., Kvitt, H., Diamant, A., Zlotkin, A., and Knibb, W. R. (2002). Strain variation in Mycobacterium marinum fish isolates. Applied and Environmental Microbiology, 68(11), 5281-5287.
  • Ulusoy, Ş., & Mol, S. (2022). Trace elements in seabass, farmed by Turkey, and health risks to the main consumers: Turkish and Dutch populations. Environmental Monitoring and Assessment, 194(3), 224.
  • Van Der Sar, A. M., Abdallah, A. M., Sparrius, M., Reinders, E., Vandenbroucke-Grauls, C. M., and Bitter, W. (2004). Mycobacterium marinum strains can be divided into two distinct types based on genetic diversity and virulence. Infection and Immunity, 72(11), 6306-6312.
  • Ziklo, N., Colorni, A., Gao, L. Y., Du, S. J., and Ucko, M. (2018). Humoral and Cellular Immune Response of European Seabass Dicentrarchus labrax Vaccinated with Heat‐Killed Mycobacterium marinum (iipA:: kan Mutant). Journal of Aquatic Animal Health, 30(4), 312-324.

Mycobacterium marinum Infection in European Sea Bass (Dicentrarchus labrax) in Brackish Water Conditions

Year 2023, Volume: 13 Issue: 4, 1570 - 1580, 15.12.2023

Ezgi Dinçtürk Ttansel Tanrıkul

https://doi.org/10.31466/kfbd.1313208

Abstract

Mycobacteriosis is a well-known zoonotic disease that affects both fish and human. The pathogen, Mycobacterium marinum, cause systemic and lethal disease in fish and can be observed in farmed and aquarium species. In this study, M.marinum infection was detected in European sea bass (Dicentrarchus labrax) with common clinical and pathological findings in brackish water conditions (3.92 ‰). Granulomas in the enlarged spleen and liver were observed. The pathogen was isolated on Löwenstein-Jensen (L-J) media and the molecular identification verified the causative agent as M.marinum. Several granulomas were detected in histopathological examination. European sea bass has one of the highest production numbers in Türkiye, and this study aims to present mycobacteriosis in detail with clinical and pathological effects on European sea bass from brackish water conditions.

Keywords

mycobacteriosis aquaculture European sea bass granulomas

References

  • Arda, M. (2006). Temel mikrobiyoloji. Medisan Yayınevi, Ankara.
  • Aronson, J. D. (1926). Spontaneous tuberculosis in salt water fish. The journal of infectious diseases, 315-320.
  • Aubry, A., Chosidow, O., Caumes, E., Robert, J., and Cambau, E. (2002). Sixty-three cases of Mycobacterium marinum infection: clinical features, treatment, and antibiotic susceptibility of causative isolates. Archives of Internal Medicine, 162(15), 1746-1752.
  • Austin, B., and Austin, D. A. (2007). Bacterial Fish Pathogens (p. 652). Heidelberg: Springer.
  • Avsever, M. L., Çavuşoğlu, C., Günen, M. Z., Yazıcıoğlu, Ö., Eskiizmirliler, S., Didinen, B. I., Tunalıgil, S., Erdal, G., and Özden, M. (2014). The first report of Mycobacterium marinum isolated from cultured meagre, Argyrosomus regius. Bulletin of the European Association of Fish Pathologists, 34(4).
  • Avsever, M. L., Çavuşoğlu, C., Eskiizmirliler, S., Türe, M., Korun, J., and Çamkerten, I. (2016). First isolation of Mycobacterium marinum from sea bass (Dicentrarchus labrax) and gilthead sea bream (Sparus auratus) cultured in Turkey. Bulletin of the European Association of Fish Pathologists, 36(5), 193
  • Brocklebank, J., Raverty, S., and Robinson, J. (2003). Mycobacteriosis in Atlantic salmon farmed in British Columbia. The Canadian Veterinary Journal, 44(6), 486.
  • Clark, R. B., Spector, H., Friedman, D. M., Oldrati, K. J., Young, C. L., and Nelson, S. C. (1990). Osteomyelitis and synovitis produced by Mycobacterium marinum in a fisherman. Journal of Clinical Microbiology, 28(11), 2570-2572.
  • Colorni, A. (1992). A systemic mycobacteriosis in the European sea bass Dicentrarchus labrax cultured in Eilat (Red Sea). Israeli Journal of Aquaculture - Bamidgeh, 44(3), 75-81.
  • Colorni, A., Avtalion, R., Knibb, W., Berger, E., Colorni, B., and Timan, B. (1998). Histopathology of sea bass (Dicentrarchus labrax) experimentally infected with Mycobacterium marinum and treated with streptomycin and garlic (Allium sativum) extract. Aquaculture, 160(1-2), 1-17.
  • Culling, A. F., Allison, T. R., and Barr, T. W. (1985). Cellular Pathology Technique, 4th Edition, London: ButterworthandCo.(Publ.)
  • Das, S., Pettersson, B. M., Behra, P. R. K., Mallick, A., Cheramie, M., Ramesh, M., Shirreff, L., DuCote, T., Dasgupta, S., Ennis, D. G., and Kirsebom, L. (2018). Extensive genomic diversity among Mycobacterium marinum strains revealed by whole genome sequencing. Scientific Reports, 8(1), 1-15.
  • Diamant, A., Banet, A., Ucko, M., Colorni, A., Knibb, W., and Kvitt, H. (2000). Mycobacteriosis in wild rabbitfish Siganus rivulatus associated with cage farming in the Gulf of Eilat, Red Sea. Diseases of Aquatic Organisms, 39(3), 211-219.
  • Dos Santos, N. M. S., Do Vale, A., Sousa, M. J., and Silva, M. T. (2002). Mycobacterial infection in farmed turbot Scophthalmus maximus. Diseases of Aquatic Organisms, 52(1), 87-91.
  • Ferreira, M., Caetano, M., Antunes, P., Costa, J., Gil, O.,Bandarra, N., Pousão-Ferreira, P., Vale, C., Reis Henriquesa, M. A. (2010). Assessment of contaminantsand biomarkers of exposure in wild and farmed sea bass. Ecotoxicology and Environmental Safety, 73, 579–588. https://doi.org/10.1016/j.ecoenv.2010.01.019
  • Gauthier, D. T., and Rhodes, M. W. (2009). Mycobacteriosis in fishes: a review. The Veterinary Journal, 180(1), 33-47.
  • Hashish, E., Merwad, A., Elgaml, S., Amer, A., Kamal, H., Elsadek, A., Marei, A., and Sitohy, M. (2018). Mycobacterium marinum infection in fish and man: epidemiology, pathophysiology and management; a review. Veterinary Quarterly, 38(1), 35-46.
  • Hedrick, R. P., McDowell, T., and Groff, J. (1987). Mycobacteriosis in cultured striped bass from California. Journal of Wildlife Diseases, 23(3), 391-395.
  • Jacobs, J. M., Stine, C. B., Baya, A. M., and Kent, M. L. (2009). A review of mycobacteriosis in marine fish. Journal of Fish Diseases, 32(2), 119-130.
  • Keller, C., Wenker, C., Jermann, T., Hirschi, R., Schildger, B., Meier, R., and Schmidt-Posthaus, H. (2018). Piscine mycobacteriosis–Involvement of bacterial species and reflection in pathology. Schweizer Archiv für Tierheilkunde, 160(6), 385-393.
  • Kent, M. L., Watral, V., Wu, M., and Bermudez, L. E. (2006). In vivo and in vitro growth of Mycobacterium marinum at homoeothermic temperatures. FEMS Microbiology Letters, 257(1), 69-75.
  • Korun, J., Olgac, V., Akgun-Dar, K., Colorni, A., and Diamant, A. (2005). Mycobacteriosis in European sea bass, l., cultured in Turkey. The Israeli Journal of Aquaculture – Bamidgeh 57(4), 215-222.
  • Kurokawa, S., Kabayama, J., Fukuyasu, T., Hwang, S. D., Park, C. I., Park, S. B.,Castillo, C.S., Hikima, J., Jung, T. S., Kondo, H., Hirono, I., Takeyama, H., and Aoki, T. (2013). Bacterial classification of fish-pathogenic Mycobacterium species by multigene phylogenetic analyses and MALDI Biotyper identification system. Marine Biotechnology, 15, 340-348.
  • Lansdell, W., Dixon, B., Smith, N., and Benjamin, L. (1993). Communications: Isolation of several mycobacterium species from fish. Journal of Aquatic Animal Health, 5(1), 73-76.
  • Lawler, A. R. (1994). Human Myobacterium marinum Aronson infections. Journal of Aquariculture and Aquatic Sciences, 6(4), 93-95.
  • Ostland, V. E., Watral, V., Whipps, C. M., Austin, F. W., St-Hilaire, S., Westerman, M. E., and Kent, M. L. (2008). Biochemical, molecular, and virulence characteristics of select Mycobacterium marinum isolates in hybrid striped bass Morone chrysops× M. saxatilis and zebrafish Danio rerio. Diseases of Aquatic Organisms, 79(2), 107-118.
  • Peña Merino, L., Mendieta-Eckert, M., Méndez Maestro, I., and Gardeazabal García, J. (2020). Infección por Mycobacterium marinum en una paciente en tratamiento con adalimumab. Actas dermo-sifiliogr.(Ed. impr.), 525-526.
  • Pidot, S. J., Asiedu, K., Käser, M., Fyfe, J. A., and Stinear, T. P. (2010). Mycobacterium ulcerans and other mycolactone-producing mycobacteria should be considered a single species. PLoS Neglected Tropical Diseases, 4(7), e663.
  • Qi, W., Käser, M., Röltgen, K., Yeboah-Manu, D., & Pluschke, G. (2009). Genomic diversity and evolution of Mycobacterium ulcerans revealed by next-generation sequencing. PLoS pathogens, 5(9), e1000580.
  • Rallis, E., and Koumantaki-Mathioudaki, E. (2007). Treatment of Mycobacterium marinum cutaneous infections. Expert Opinion on Pharmacotherapy, 8(17), 2965-2978.
  • Ravid-Peretz, S., Colorni, A., Sharon, G., and Ucko, M. (2019). Vaccination of European sea bass Dicentrarchus labrax with avirulent Mycobacterium marinum (iipA:: kan mutant). Fish & Shellfish Immunology, 90, 317-327.
  • Roberts, R. J. (2001). The bacteriology of teleosts. Fish pathology, (Ed. 3).
  • Slany, M., Makovcova, J., Jezek, P., Bodnarova, M., and Pavlik, I. (2014). Relative prevalence of Mycobacterium marinum in fish collected from aquaria and natural freshwaters in central Europe. Journal of Fish Diseases, 37(6), 527-533.
  • Tamura, K., Stecher, G., Kumar, S. (2021) MEGA11: Molecular Evolutionary Genetics Analysis version 11. Molecular Biology and Evolution 38:3022-3027
  • Tanrıkul, T.,T and Dinçtürk, E. (2021). A New Outbreak in Sea Bass Farming in Turkey: Aeromonas veronii. Journal of the Hellenic Veterinary Medical Society, 72(3), 3051-3058.
  • Timur, G., Ürkü, Ç., Çanak, Ö. G., Genç, E., Erturan, Z. (2015). Systemic mycobacteriosis caused by Mycobacterium marinum in farmed meagre (Argyrosomus regius), in Turkey. Israeli Journal of Aquaculture - Bamidgeh, 67, 1–8.
  • TUIK (2023). Fishery Statistics (https://data.tuik.gov.tr/Kategori/GetKategori?p=tarim-111&dil=1) (September / 2023).
  • Ucko, M., Colorni, A., Kvitt, H., Diamant, A., Zlotkin, A., and Knibb, W. R. (2002). Strain variation in Mycobacterium marinum fish isolates. Applied and Environmental Microbiology, 68(11), 5281-5287.
  • Ulusoy, Ş., & Mol, S. (2022). Trace elements in seabass, farmed by Turkey, and health risks to the main consumers: Turkish and Dutch populations. Environmental Monitoring and Assessment, 194(3), 224.
  • Van Der Sar, A. M., Abdallah, A. M., Sparrius, M., Reinders, E., Vandenbroucke-Grauls, C. M., and Bitter, W. (2004). Mycobacterium marinum strains can be divided into two distinct types based on genetic diversity and virulence. Infection and Immunity, 72(11), 6306-6312.
  • Ziklo, N., Colorni, A., Gao, L. Y., Du, S. J., and Ucko, M. (2018). Humoral and Cellular Immune Response of European Seabass Dicentrarchus labrax Vaccinated with Heat‐Killed Mycobacterium marinum (iipA:: kan Mutant). Journal of Aquatic Animal Health, 30(4), 312-324.
There are 41 citations in total.

Details

Primary Language English
Subjects Aquaculture and Fisheries (Other)
Journal Section Articles
Authors

Ezgi Dinçtürk 0000-0002-5826-2383

Ttansel Tanrıkul 0000-0002-1684-7965

Early Pub Date December 18, 2023
Publication Date December 15, 2023
Published in Issue Year 2023 Volume: 13 Issue: 4

Cite

APA Dinçtürk, E., & Tanrıkul, T. (2023). Mycobacterium marinum Infection in European Sea Bass (Dicentrarchus labrax) in Brackish Water Conditions. Karadeniz Fen Bilimleri Dergisi, 13(4), 1570-1580. https://doi.org/10.31466/kfbd.1313208
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