Research Article
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Investigation of thyroid hormone levels and body composition values in obese adolescents

Year 2019, Volume: 16 Issue: 1, 17 - 23, 22.03.2019

Abstract

Background: It is very important to determine the factors affecting the formation of obesity and solve the health problems that may develop during adolescence and take necessary precautions. Thus, we aimed to retrospectively investigate the relationship between thyroid hormone levels and lipid profiles, which play important roles in the development of obesity, and body composition in obese adolescents. Methods: The study population consisted of 45 obese, 48 overweight and 33 healthy adolescent girls, whose body compositions and biochemical parameters were measured at Batman State Hospital Diet Policlinic on the same day. Adolescents' obesity status, body composition parameters including muscle, bone and fat weight, fat content and basal metabolic rate were examined. Serum insulin levels, free thyroxine, and thyroid stimulating hormone and lipid profiles were also examined in the participants. Results: Obese adolescents had significantly higher total cholesterol, triglyceride and low-density lipoprotein levels than normal weight and overweight adolescents. The obese adolescents' thyroid stimulating hormone levels were significantly higher than the control group. Conclusion: These findings indicate that thyroid stimulating hormone levels significantly changed in obese adolescent girls. However, it may be suggested that clarification of the factors involved in the change of these hormone levels may contribute to the prevention of adolescence obesity and obesity related complications.

References

  • 1.Güngör NK. Overweight and obesity in children and adolescents. J Clin Res Pediatr Endocrinol 2014;6(3):129-43.
  • 2.Atabek ME, Pirgon O, Kurtoglu S. Prevalence of metabolic syndrome in obese Turkish children and adolescents. Diabetes Res Clin Pract. 2006;72(3):315-21.
  • 3.Bastemir M, Akin F, Alkis E, Kaptanoglu B. Obesity is associated with increased serum TSH level, independent of thyroid function. Swiss Med Wkly. 2007;137(29-30):431-4.
  • 4.Altunoğlu E, Ülgen E, Müderrisoğlu C, Erdenen F, Boz M. Obezite Ve Tiroid Fonksiyonları, İstanbul Tıp Derg 2011;12 (2): 69-71.
  • 5.Bhowmick SK, Dasari G, Levens KL, Rettig KR. The prevalence of elevated serum thyroid-stimulating hormone in childhood/adolescent obesity and of autoimmune thyroid diseases in a subgroup. J Natl Med Assoc 2007;99(7):773-6.
  • 6.Fuller NJ, Fewtrell MS, Dewit O, Elia M, Wells JC. Segmental bioelectrical impedance analysis in children aged 8-12 y: 2. The assessment of regional body composition and muscle mass. Int J Obes Relat Metab Disord 2002;26(5):692-700.
  • 7.Camina Martín MA, de Mateo Silleras B, Redondo del Río MP. Body composition analysis in older adults with dementia. Anthropometry and bioelectrical impedance analysis: a critical review. Eur J Clin Nutr 2014;68(11):1228-33.
  • 8.Boyraz M. Çocuklarda Obezite ve Tiroid Fonksiyon Testleri ilişkisi (Relationship between obesity and thyroid function tests in children), Yeni Tıp Dergisi 2013;30: 160-163.
  • 9.Bundak R, Furman A., Gunoz, H., Darendeliler, F., Bas, F. ve Neyzi, O., 2006, Body mass index references for Turkish children, Acta Paediatr, 95 (2), 194-198.
  • 10.Martelletti P, Andreoli A, Bernoni RM, Di Sabato F, Del Bolgia F, Baldi A, Sasso GF, Barra P, De Lorenzo A, Giacovazzo M. Bioelectrical impedance assay (BIA) of total body composition in alcohol-induced migraine patients. Preliminary report. Headache 1991;31(1):41-5.
  • 11.Camina Martín MA, de Mateo Silleras B, Redondo del Río MP. Body composition analysis in older adults with dementia. Anthropometry and bioelectrical impedance analysis: a critical review. Eur J Clin Nutr 2014;68(11):1228-33.
  • 12.Boyd GS, Koenigsberg J, Falkner B, Gidding S, Hassink S. Effect of obesity and high blood pressure on plasma lipid levels in children and adolescents. Pediatrics 2005;116(2):442-6.
  • 13.Reinehr T, Kiess W, de Sousa G, Stoffel-Wagner B, Wunsch R. Intima media thickness in childhood obesity: relations to inflammatory marker, glucose metabolism, and blood pressure. Metabolism 2006;55(1):113-8. 14.Hashemipour M, Soghrati M, Malek Ahmadi M, Soghrati M. Anthropometric indices associated with dyslipidemia in obese children and adolescents: a retrospective study in isfahan. ARYA Atheroscler 2011;7(1):31-9.
  • 15.Lunardi CC, Petroski EL. Body mass index as a marker of dyslipidemia in children. Arq Bras Cardiol 2009;93(1):22-7.
  • 16.Krotkiewski M. Thyroid hormones in the pathogenesis and treatment of obesity. Eur J Pharmacol 2002;440(2-3):85-98.
  • 17.Bhowmick SK, Dasari G, Levens KL, Rettig KR. The prevalence of elevated serum thyroid-stimulating hormone in childhood/adolescent obesity and of autoimmune thyroid diseases in a subgroup. J Natl Med Assoc 2007;99(7):773-6.
  • 18.Boyraz M. Çocuklarda Obezite ve Tiroid Fonksiyon Testleri ilişkisi (Relationship between obesity and thyroid function tests in children. Yeni Tıp Dergisi 2013; 30: 160-3.
  • 19.Nader NS, Bahn RS, Johnson MD, Weaver AL, Singh R, Kumar S. Relationships between thyroid function and lipid status or insulin resistance in a pediatric population. Thyroid. 2010;20(12):1333-9.
  • 20.Mutlu G, Özsu E, Çizmecioğlu F, Hatun Ş. Şişman çocuklarda hafif TSH yüksekliği: Nasıl bir sorun?, Türk Ped Arş 2011;46: 33-36.
  • 21.Karakurt F, Çarkoğlu A, Köroğlu M, Us B, Kasapoğlu B. Tiroid fonksiyonları obezite için bir risk faktörü müdür? Yeni Tıp Dergisi 2009;26: 27-30.
  • 22.Kazma E. Üniversite Öğrencileri Arasında Obezite Prevalansı Ve Oluşum Nedenlerinin Saptanması, Yüksek Lisans Tezi, Fen Bilimleri Enstitüsü, İstanbul Aydın Üniversitesi, İstanbul. 2013;16-19.
  • 23.Neymotin F, Sen U. Iron and obesity in females in the United State, Obesity (Silver Spring) 2011;19 (1): 191-9.
  • 24.Manios Y, Moschonis G, Chrousos GP, Lionis C, Mougios V, Kantilafti M, Tzotzola V, Skenderi KP, Petridou A, Tsalis G, Sakellaropoulou A, Skouli G, Katsarou C. The double burden of obesity and iron deficiency on children and adolescents in Greece: the Healthy Growth Study. J Hum Nutr Diet 2013;26(5):470-8. 25.Jehn M, Clark JM, Guallar E. Serum ferritin and risk of the metabolic syndrome in U.S. adults, Diabetes Care 2004;27 (10): 2422-8.
  • 26.Gilbert-Diamond D, Baylin A, Mora-Plazas M, Villamor E. Chronic inflammation is associated with overweight in Colombian school children, Nutr Metab Cardiovasc Dis 2012;22 (3): 244-51.

Obez Adolesanlarda Tiroid Hormon Düzeyleri ve Vücut Kompozisyon Değerlerinin İncelenmesi

Year 2019, Volume: 16 Issue: 1, 17 - 23, 22.03.2019

Abstract

Amaç: Obezite oluşumunu etkileyen faktörleri belirlemek, ergenlik döneminde ortaya çıkabilecek sağlık sorunlarını çözmek ve gerekli önlemleri almak çok önemlidir. Bu nedenle obezite gelişiminde rol oynayan tiroid hormon düzeyleri ve lipid profilleri ile vücut kompozisyonu arasındaki ilişkiyi obez ergenlerde retrospektif olarak incelemeyi amaçladık. Materyal ve metod: Çalışma grubu, aynı gün içinde Batman Devlet Hastanesi Diyet Polikliniği'nde vücut kompozisyonu ve biyokimyasal parametreleri ölçülen 45 obez, 48 aşırı kilolu ve 33 sağlıklı ergen kızdan oluştu. Adolesanların obezite durumu, kas, kemik ve yağ ağırlığı, yağ içeriği ve bazal metabolik hızının da dahil olduğu vücut kompozisyonu parametreleri incelendi. Adolesan kızlarda serum insülin düzeyleri, serbest tiroksin, tiroid uyarıcı hormon ve lipit profilleri de incelenmiştir. Bulgular: Obez ergenlerin normal kilolu ve aşırı kilolu ergenlere göre total kolesterol, trigliserit ve düşük dansiteli lipoprotein düzeyleri anlamlı olarak daha yüksekdi. Obez ergenlerde tiroid uyarıcı hormon düzeyleri kontrol grubundan anlamlı derecede yüksekdi. Sonuç: Bu bulgular obez ergen kızlarda tiroid uyarıcı hormon düzeylerinin anlamlı olarak değiştiğini göstermektedir. Ayrıca, bu hormon seviyelerinin değişmesinde rol oynayan faktörlerin açıklığa kavuşturulmasının, adolesan obezitesinin ve obezite ile ilgili komplikasyonların önlenmesine katkıda bulunabileceği öne sürülebilir.

References

  • 1.Güngör NK. Overweight and obesity in children and adolescents. J Clin Res Pediatr Endocrinol 2014;6(3):129-43.
  • 2.Atabek ME, Pirgon O, Kurtoglu S. Prevalence of metabolic syndrome in obese Turkish children and adolescents. Diabetes Res Clin Pract. 2006;72(3):315-21.
  • 3.Bastemir M, Akin F, Alkis E, Kaptanoglu B. Obesity is associated with increased serum TSH level, independent of thyroid function. Swiss Med Wkly. 2007;137(29-30):431-4.
  • 4.Altunoğlu E, Ülgen E, Müderrisoğlu C, Erdenen F, Boz M. Obezite Ve Tiroid Fonksiyonları, İstanbul Tıp Derg 2011;12 (2): 69-71.
  • 5.Bhowmick SK, Dasari G, Levens KL, Rettig KR. The prevalence of elevated serum thyroid-stimulating hormone in childhood/adolescent obesity and of autoimmune thyroid diseases in a subgroup. J Natl Med Assoc 2007;99(7):773-6.
  • 6.Fuller NJ, Fewtrell MS, Dewit O, Elia M, Wells JC. Segmental bioelectrical impedance analysis in children aged 8-12 y: 2. The assessment of regional body composition and muscle mass. Int J Obes Relat Metab Disord 2002;26(5):692-700.
  • 7.Camina Martín MA, de Mateo Silleras B, Redondo del Río MP. Body composition analysis in older adults with dementia. Anthropometry and bioelectrical impedance analysis: a critical review. Eur J Clin Nutr 2014;68(11):1228-33.
  • 8.Boyraz M. Çocuklarda Obezite ve Tiroid Fonksiyon Testleri ilişkisi (Relationship between obesity and thyroid function tests in children), Yeni Tıp Dergisi 2013;30: 160-163.
  • 9.Bundak R, Furman A., Gunoz, H., Darendeliler, F., Bas, F. ve Neyzi, O., 2006, Body mass index references for Turkish children, Acta Paediatr, 95 (2), 194-198.
  • 10.Martelletti P, Andreoli A, Bernoni RM, Di Sabato F, Del Bolgia F, Baldi A, Sasso GF, Barra P, De Lorenzo A, Giacovazzo M. Bioelectrical impedance assay (BIA) of total body composition in alcohol-induced migraine patients. Preliminary report. Headache 1991;31(1):41-5.
  • 11.Camina Martín MA, de Mateo Silleras B, Redondo del Río MP. Body composition analysis in older adults with dementia. Anthropometry and bioelectrical impedance analysis: a critical review. Eur J Clin Nutr 2014;68(11):1228-33.
  • 12.Boyd GS, Koenigsberg J, Falkner B, Gidding S, Hassink S. Effect of obesity and high blood pressure on plasma lipid levels in children and adolescents. Pediatrics 2005;116(2):442-6.
  • 13.Reinehr T, Kiess W, de Sousa G, Stoffel-Wagner B, Wunsch R. Intima media thickness in childhood obesity: relations to inflammatory marker, glucose metabolism, and blood pressure. Metabolism 2006;55(1):113-8. 14.Hashemipour M, Soghrati M, Malek Ahmadi M, Soghrati M. Anthropometric indices associated with dyslipidemia in obese children and adolescents: a retrospective study in isfahan. ARYA Atheroscler 2011;7(1):31-9.
  • 15.Lunardi CC, Petroski EL. Body mass index as a marker of dyslipidemia in children. Arq Bras Cardiol 2009;93(1):22-7.
  • 16.Krotkiewski M. Thyroid hormones in the pathogenesis and treatment of obesity. Eur J Pharmacol 2002;440(2-3):85-98.
  • 17.Bhowmick SK, Dasari G, Levens KL, Rettig KR. The prevalence of elevated serum thyroid-stimulating hormone in childhood/adolescent obesity and of autoimmune thyroid diseases in a subgroup. J Natl Med Assoc 2007;99(7):773-6.
  • 18.Boyraz M. Çocuklarda Obezite ve Tiroid Fonksiyon Testleri ilişkisi (Relationship between obesity and thyroid function tests in children. Yeni Tıp Dergisi 2013; 30: 160-3.
  • 19.Nader NS, Bahn RS, Johnson MD, Weaver AL, Singh R, Kumar S. Relationships between thyroid function and lipid status or insulin resistance in a pediatric population. Thyroid. 2010;20(12):1333-9.
  • 20.Mutlu G, Özsu E, Çizmecioğlu F, Hatun Ş. Şişman çocuklarda hafif TSH yüksekliği: Nasıl bir sorun?, Türk Ped Arş 2011;46: 33-36.
  • 21.Karakurt F, Çarkoğlu A, Köroğlu M, Us B, Kasapoğlu B. Tiroid fonksiyonları obezite için bir risk faktörü müdür? Yeni Tıp Dergisi 2009;26: 27-30.
  • 22.Kazma E. Üniversite Öğrencileri Arasında Obezite Prevalansı Ve Oluşum Nedenlerinin Saptanması, Yüksek Lisans Tezi, Fen Bilimleri Enstitüsü, İstanbul Aydın Üniversitesi, İstanbul. 2013;16-19.
  • 23.Neymotin F, Sen U. Iron and obesity in females in the United State, Obesity (Silver Spring) 2011;19 (1): 191-9.
  • 24.Manios Y, Moschonis G, Chrousos GP, Lionis C, Mougios V, Kantilafti M, Tzotzola V, Skenderi KP, Petridou A, Tsalis G, Sakellaropoulou A, Skouli G, Katsarou C. The double burden of obesity and iron deficiency on children and adolescents in Greece: the Healthy Growth Study. J Hum Nutr Diet 2013;26(5):470-8. 25.Jehn M, Clark JM, Guallar E. Serum ferritin and risk of the metabolic syndrome in U.S. adults, Diabetes Care 2004;27 (10): 2422-8.
  • 26.Gilbert-Diamond D, Baylin A, Mora-Plazas M, Villamor E. Chronic inflammation is associated with overweight in Colombian school children, Nutr Metab Cardiovasc Dis 2012;22 (3): 244-51.
There are 24 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Research Article
Authors

Sedat Bulut This is me 0000-0003-0994-4772

Selçuk Akın This is me 0000-0001-9154-6030

İhsan Çetin 0000-0002-0937-0054

Elif Değirmen This is me 0000-0002-7820-4180

Umut Durak This is me 0000-0002-1710-395X

Publication Date March 22, 2019
Submission Date October 22, 2018
Acceptance Date February 3, 2019
Published in Issue Year 2019 Volume: 16 Issue: 1

Cite

Vancouver Bulut S, Akın S, Çetin İ, Değirmen E, Durak U. Obez Adolesanlarda Tiroid Hormon Düzeyleri ve Vücut Kompozisyon Değerlerinin İncelenmesi. Harran Üniversitesi Tıp Fakültesi Dergisi. 2019;16(1):17-23.

Harran Üniversitesi Tıp Fakültesi Dergisi  / Journal of Harran University Medical Faculty